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Results for "

σ1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    53
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
Amitriptyline hydrochloride
Tryptizol, Domical, Annoyltin, Amitriptyline HCl
T0678549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
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s1ra
E-52862
T1865878141-96-9
S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM).
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7-10 days
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TargetMol | Citations Cited
AB21 HCl
T77340L
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity.
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σ1 Receptor antagonist-1
T92441204401-49-9
σ1 Receptor antagonist-1 is a selective σ1 receptor antagonist.
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σ1 Receptor/μ Opioid receptor modulator 1
T619012412700-00-4
σ 1 Receptor μ Opioid receiver modulator 1 (Compound 44) is an effective σ 1 receptor antagonist (Ki=1.86 nM) and μ Opioid receptor agonists (Ki=2.1 nM). Opioid receptor modulator 1 shows potent analgesic activity, and can be used for the research of neuropathic pain.
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6-8 weeks
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σ1 Receptor ligand 1
T201225
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.
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S1R agonist 2
T72059150085-21-5In house
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
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KSK94
T795002566716-07-0In house
KSK94 is a specific H3 receptor antagonist that inhibits H3, sigma-1, and sigma-2 receptors , with Ki values of 7.9, 2958, and 75.2 nM, respectively, and can be used to study injurious pain and neuropathic pain.
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6-8weeks
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OPC-14523 hydrochloride
VPI 013 hydrochloride
T62711145969-31-9In house
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity, showing high affinity for the sigma receptor σ1 2 (IC50=47 56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM).
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6-8 weeks
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KSK68
T794992566715-91-9In house
KSK68 is a potent dual sigma-1 and histamine H3 receptor antagonist with potential analgesic activity and high affinity for H3 receptors, sigma-1, sigma-2 receptors.KSK68 can be used in the study of pain related diseases.
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6-8weeks
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Pridopidine
ACR16, ASP2314, FR310826
T7352346688-38-8In house
Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6 2 mouse model.
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Sigma-1 receptor antagonist 2
T129111639220-15-7In house
Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of the sigma-1 receptor (σ1 R, Ki = 3.88 nM) compared to the sigma-2 receptor (Ki = 1288 nM).
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6-8 weeks
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Sigma-1 receptor antagonist 3
T129121639220-17-9In house
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
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6-8 weeks
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Ditolylguanidine
DTG, Di-o-tolylguanidine, 1,3-Di-o-tolylguanidine
T596997-39-2
Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1 σ2 receptor).
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OPC-14523 free base
VPI-013, VPI013, VPI 013, OPC-14523, OPC 14523, OPC14523
T28256145969-30-8In house
OPC-14523, a 5-HT1A receptor agonist, is used potentially for the treatment of depression and neuropathic pain.
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6-8 weeks
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BD-1047 dihydrobromide
BD1047.2HBr
T1740138356-21-5
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
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S1RA hydrochloride
E-52862 hydrochloride
T42291265917-14-3
S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
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BD1063 dhydrochloride
BD1063 2HCL
T7488206996-13-6
BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).
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TargetMol | Citations Cited
BD 1008 dihydrobromide
T21788138356-09-9
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors.
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4-PPBP maleate
T22513201216-39-9
4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a 2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
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6-8 weeks
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PD 144418 oxalate
T392111794760-28-3
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand with a Ki value of 0.08 nM for σ1 and 1377 nM for σ2, exhibiting negligible affinity for other receptors, ion channels, and enzymes, and demonstrating potential antipsychotic activity.
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4-IBP
T4596155798-08-6
4-IBP is a selective σ1 agonist with high affinity for the σ1 receptor (Ki = 1.7 nM) and moderate affinity for the σ2 receptor (Ki = 25.2 nM).
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Sigma-1 receptor antagonist 1
T129101639220-19-1
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.
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6-8 weeks
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EST73502 HCl
T392842535970-65-9
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
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