DMPE-PEG350 is a PEG lipid functional end group used for synthesizing liposomes (LPs) and designing conjugated polymer nanoparticles. These liposomal nanoparticles (LNPs), featuring biotin modification and a carboxyl end, can further couple with other biomolecules. Functionalized nanoparticles are applicable in the targeted labeling of specific cell proteins. Using streptavidin as a linker, the biotinylated PEG lipid-conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, facilitating fluorescence-based imaging and sensing applications.