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Ropivacaine mesylate

Catalog No. T61475 CAS 854056-07-8

Ropivacaine mesylate, a long-acting amide local anaesthetic, is used for spinal block and effectively mitigates neuropathic pain. It achieves analgesia by reversibly inhibiting sodium ion influx in nerve fibers, thus blocking impulse conduction. Additionally, Ropivacaine acts as an inhibitor of the K2P (two-pore domain potassium channel) TREK-1, exhibiting an IC50 of 402.7 μM in COS-7 cell membranes.

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Ropivacaine mesylate, CAS 854056-07-8

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Biological Description

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Description

In vivo

Epidural administration of Ropivacaine mesylate effectively mitigates neuropathic pain, including mechanical allodynia and heat hyperalgesia, without leading to analgesic tolerance, and notably delays neuropathic pain onset following peripheral nerve damage. Furthermore, it restrains increases in the filtration coefficient induced by pressure, without altering pulmonary artery, capillary pressures, or zonal characteristics. This compound also prevents pressure-induced lung edema and hyperpermeability, maintaining oxygen levels, lung moisture balance, and plasma volume at normal rates, similar to control (sham) rats. Additionally, it reduces pressure-stimulated nitric oxide production, evidenced by lower nitro-tyrosine levels in the lungs compared to those in hypertensive conditions. The research utilized adult Sprague-Dawley rats, with a dosage of 1 μM Ropivacaine mesylate delivered via infusion into the perfusate reservoir, demonstrating its ability to attenuate pressure-related increases in the filtration coefficient.

Molecular Weight	370.51
Formula	C18H30N2O4S
CAS No.	854056-07-8

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Ropivacaine mesylate 854056-07-8 inhibitor inhibit

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