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AZD9056 hydrochloride

🥰Excellent
Catalog No. T14385Cas No. 345303-91-5

AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.

AZD9056 hydrochloride
Other Forms of AZD9056 hydrochloride:
AZD-9056 free baseT30267345304-65-6
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AZD9056 hydrochloride

🥰Excellent
Purity: 99.68%
Catalog No. T14385Cas No. 345303-91-5
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$34In StockIn Stock
5 mg$56In StockIn Stock
10 mg$95In StockIn Stock
25 mg$211In StockIn Stock
50 mg$352In StockIn Stock
100 mg$503In StockIn Stock
1 mL x 10 mM (in DMSO)$59In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.68%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
Targets&IC50
P2X7:11.2 nM
In vitro
The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in the HEK-hP2X7 cell line, indicating high selectivity for the receptor. Additionally, AZD9056 exhibits a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1].
In vivo
Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues.
Chemical Properties
Molecular Weight455.46
FormulaC24H36Cl2N2O2
Cas No.345303-91-5
SmilesCl.OCCCNCCCc1ccc(Cl)c(c1)C(=O)NCC12CC3CC(CC(C3)C1)C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 48 mg/mL (105.39 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.39 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1956 mL10.9779 mL21.9558 mL109.7791 mL
5 mM0.4391 mL2.1956 mL4.3912 mL21.9558 mL
10 mM0.2196 mL1.0978 mL2.1956 mL10.9779 mL
20 mM0.1098 mL0.5489 mL1.0978 mL5.4890 mL
50 mM0.0439 mL0.2196 mL0.4391 mL2.1956 mL
100 mM0.0220 mL0.1098 mL0.2196 mL1.0978 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

P2XRsP2XReceptorP2X7P2X ReceptorInhibitorinhibitAZD-9056 HydrochlorideAZD-9056 hydrochlorideAZD9056 hydrochlorideAZD9056 HydrochlorideAZD-9056AZD9056AZD 9056 HydrochlorideAZD 9056
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