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ML204 hydrochloride

Name: ML204 hydrochloride
Brand: TargetMol
SKU: T24481
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24481Cas No. 2070015-10-8

Alias ML204 HCl

ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).

ML204 hydrochloride

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Catalog No. T24481Alias ML204 HClCas No. 2070015-10-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$49	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).
Targets&IC50	TRPC4β-mediated increase in intracellular Ca²⁺:0.96 μM
In vitro	ML204 hydrochloride inhibited TRPC4β-mediated increase in intracellular Ca²⁺ (HEK293 cells) at an IC50 value of 0.96 μM with 19-fold selectivity for muscarinic receptor-activated TRPC6 channels. [1] ML204 hydrochloride inhibits TRPC4β activity by blocking u-opioid, 5HT1A serotonin, Gi/o activation, and M2 muscarinic receptor or endogenous M3-like muscarinic receptor-stimulated Gq/11 pathways. [2] ML204 hydrochloride Inhibits LPS-induced TRPC5 channel function. [3]
In vivo	In an LPS-treated mouse model, ML204 hydrochloride (1 mg/kg; subcutaneous; twice daily for 5 days) increased the risk of death associated with severe hypothermia and decreased the number of peritoneal leukocytes and cytokines. [4]
Synonyms	ML204 HCl

Chemical Properties

Molecular Weight	262.78
Formula	C₁₅H₁₉ClN₂
Cas No.	2070015-10-8
Smiles	Cl.N=1C=2C=CC=CC2C(=CC1N3CCCCC3)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (76.11 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.8055 mL	19.0273 mL	38.0546 mL	190.2732 mL
5 mM	0.7611 mL	3.8055 mL	7.6109 mL	38.0546 mL
10 mM	0.3805 mL	1.9027 mL	3.8055 mL	19.0273 mL
20 mM	0.1903 mL	0.9514 mL	1.9027 mL	9.5137 mL
50 mM	0.0761 mL	0.3805 mL	0.7611 mL	3.8055 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc