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TargetMol | Tags Metabolism
TargetMol | Tags Stem Cells

Casein Kinase

casein kinase (CK) is a highly conserved enzyme that catalyzes serine/threonine phosphorylation of adjacent acidic amino acid residues in the peptide chain. These include casein kinase 1(CK1) and casein kinase 2(CK2).

LY294002
T2008154447-36-6
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5 0.57 0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
  • $34
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Silmitasertib
T22591009820-21-6
Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
  • $34
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XL413 hydrochloride
T67352062200-97-7
XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.
  • $48
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iwp-2
T2702686770-61-6
IWP-2 is a Wnt pathway inhibitor (IC50=27 nM) and an ATP-competitive CK1δ inhibitor (IC50=40 nM for M82FCK1δ). IWP-2 inhibits self-renewal of embryonic stem cells and has been used in stem cell and organoid research.
  • $43
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as-252424
T6208900515-16-4
AS-252424 is a potent and selective inhibitor of PI3Kγ with an IC50 of 33 nM and demonstrates over 10-fold selectivity for PI3Kγ versus PI3Kα.
  • $33
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PF-670462
T3073950912-80-8
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
  • $42
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D4476
T2449301836-43-1
D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
  • $36
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Ellagic acid
T0465476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity.
  • $44
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PF-4800567
T50561188296-52-7
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
  • $38
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Emodin
T2869518-82-1
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.
  • $45
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TBB
T269517374-26-4
TBB (NSC-231634)(NSC-231634) is a highly selective, ATP GTP-competitive inhibitor of casein kinase-2 (CK2).
  • $38
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SR-1277
T389271446715-47-4
SR-1277 is a potent, highly selective and ATP-competitive CK1δ ε inhibitor with IC50 values of 49 nM and 260 nM, respectively.CK1δ plays a crucial role in regulating Wee1 activity at the G2 M cell-cycle interface, and exhibits significant antiproliferative activity against a variety of cancer cells.
  • $397
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LY-364947
T2048396129-53-6
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
  • $59
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WAY-297174
T60067442571-27-9
WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
  • $76
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A-443654
T14072552325-16-3
A-443654, a pan-Akt inhibitor, exhibits equal potency against Akt1, Akt2, and Akt3 within cells (Ki=160 pM).
  • $84
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SGC-CK2-1
T401312470424-39-4
SGC-CK2-1 is a highly specific inhibitor of CK2, a inducer of insulin production and secretion in pancreatic β-cells, and can be used in the study of neurodegenerative diseases.
  • $53
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Silmitasertib sodium salt
T150241309357-15-0
Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
  • $30
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XL413
T33521169558-38-6In house
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induct
  • $48
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Casein Kinase inhibitor A51
T91752079068-74-7
Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, breast and prostate cancers.
  • $399
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CK2/ERK8-IN-1
T108271085822-09-8In house
CK2 ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2 ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
  • $30
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MLN8054
T6315869363-13-3
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
  • $48
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Casein Kinase II Inhibitor IV
T10687863598-09-8In house
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
  • $79
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Casein kinase 1δ-IN-6
T775001579991-01-7
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.
  • $129
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XL413 xHCl
T713391169562-71-3
XL413 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.XL413 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.XL413 HCl showed an EC50 value of 118 against pMCM.
  • $57
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