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JNJ-67856633

Name: JNJ-67856633
Brand: TargetMol
SKU: T36670
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36670Cas No. 2230273-76-2

JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.

JNJ-67856633

🥰Excellent

Purity: 99.87%

Catalog No. T36670Cas No. 2230273-76-2

JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$189	In Stock
25 mg	$326	In Stock
50 mg	$485	In Stock
100 mg	$728	In Stock
200 mg	$982	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock

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Purity:99.87%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.
In vitro	JNJ-67856633 is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. JNJ-67856633 results in potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors[1][3].
In vivo	Treatment with JNJ-67856633 was observed to cause dose-dependent inhibition of Tregs (CD4+CD25+FoxP3+) generation following CD3/28 stimulation, suggesting a potential immune-modulatory role of MALT1 inhibition[3].

Chemical Properties

Molecular Weight	467.32
Formula	C₂₀H₁₁F₆N₅O₂
Cas No.	2230273-76-2
Smiles	FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1ccnc(c1)C(F)(F)F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (267.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1399 mL	10.6993 mL	21.3986 mL	106.9931 mL
5 mM	0.4280 mL	2.1399 mL	4.2797 mL	21.3986 mL
10 mM	0.2140 mL	1.0699 mL	2.1399 mL	10.6993 mL
20 mM	0.1070 mL	0.5350 mL	1.0699 mL	5.3497 mL
50 mM	0.0428 mL	0.2140 mL	0.4280 mL	2.1399 mL
100 mM	0.0214 mL	0.1070 mL	0.2140 mL	1.0699 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc