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Thalifendine

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Catalog No. T125531Cas No. 18207-71-1

Thalifendine is one of the main products of Berberine demethylation catalyzed by CYP51 (secreted by intestinal flora), which has anti-inflammatory effects, reduces intestinal inflammation, improves intestinal barrier function, and reduces the production of inflammatory factors.

Thalifendine
Other Forms of Thalifendine:
Thalifendine chlorideT756404668-19-3
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Thalifendine

😃Good
Catalog No. T125531Cas No. 18207-71-1
Thalifendine is one of the main products of Berberine demethylation catalyzed by CYP51 (secreted by intestinal flora), which has anti-inflammatory effects, reduces intestinal inflammation, improves intestinal barrier function, and reduces the production of inflammatory factors.
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1 mg$670 In Stock
5 mg$1,428 7-10 days
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Product Introduction

Bioactivity
Description
Thalifendine is one of the main products of Berberine demethylation catalyzed by CYP51 (secreted by intestinal flora), which has anti-inflammatory effects, reduces intestinal inflammation, improves intestinal barrier function, and reduces the production of inflammatory factors.
Targets&IC50
CYP2D6 (human liver microsomes, without preincubation):20.6 μM, CYP2D6 (human liver microsomes, after preincubation):6.49 μM
In vitro
Thalifendine showed metabolism-dependent inhibition of CYP2D6 in human liver microsomes, with the IC₅₀ decreasing from 20.6 μM to 6.49 μM after preincubation, indicating moderate inhibitory activity weaker than that of berberine[1].
Chemical Properties
Molecular Weight322.34
FormulaC19H16NO4
Cas No.18207-71-1
SmilesOC=1C=CC2=CC=3C4=CC=5OCOC5C=C4CC[N+]3C=C2C1OC
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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