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(R)-CR8 trihydrochloride

Name: (R)-CR8 trihydrochloride
Brand: TargetMol
SKU: T12617
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12617Cas No. 1786438-30-9

Alias CR8, (R)-Isomer trihydrochloride

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.

(R)-CR8 trihydrochloride

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Purity: 99.33%

Catalog No. T12617Alias CR8, (R)-Isomer trihydrochlorideCas No. 1786438-30-9

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	-	In Stock
5 mg	$56	-	In Stock
10 mg	$85	-	In Stock
25 mg	$155	-	In Stock
50 mg	$233	-	In Stock
100 mg	$328	-	In Stock
200 mg	$489	-	In Stock
1 mL x 10 mM (in DMSO)	$67	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.33%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.
Targets&IC50	CDK2-CyclinE:0.041 μM, CDK1:0.09 μM, CDK7-CyclinH:1.1 μM, CDK5-p25:0.11 μM, CDK2:0.072 μM, CDK9-CyclinT1:0.18 μM, CK1δ/ε:0.4 μM
In vitro	In the SH-SY5Y cell line, (R)-CR8 trihydrochloride (0.1, 1, 10, 100 μM; 24 hours) reduced cell survival in a dose-dependent manner[1].
In vivo	In 10 to 12-week-old male Sprague-Dawley rats (310 to 330 g), administration of (R)-CR8 trihydrochloride at 5 mg/kg (i.p.) resulted in a significant reduction in lesion size[2].
Synonyms	CR8, (R)-Isomer trihydrochloride

Chemical Properties

Molecular Weight	540.92
Formula	C₂₄H₃₂Cl₃N₇O
Cas No.	1786438-30-9
Smiles	Cl.Cl.Cl.CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (55.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8487 mL	9.2435 mL	18.4870 mL	92.4351 mL
5 mM	0.3697 mL	1.8487 mL	3.6974 mL	18.4870 mL
10 mM	0.1849 mL	0.9244 mL	1.8487 mL	9.2435 mL
20 mM	0.0924 mL	0.4622 mL	0.9244 mL	4.6218 mL
50 mM	0.0370 mL	0.1849 mL	0.3697 mL	1.8487 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc