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Osunprotafib

Catalog No. T61699 CAS 2489404-97-7

Synonyms: AC 484, Osunprotafib, AC484, ABBV-CLS-484

ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cancer, and digestive disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Osunprotafib, CAS 2489404-97-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 455.00
2 mg	In stock	$ 729.00
5 mg	In stock	$ 1,150.00
10 mg	In stock	$ 1,550.00
25 mg	In stock	$ 2,290.00
50 mg	In stock	$ 2,970.00
100 mg	In stock	$ 4,180.00

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Purity: 97.45%

Biological Description

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Description	ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cancer, and digestive disorders.
In vitro	ABBV-CLS-484 acts simultaneously on tumor cells and the host immune system, inducing unique transcriptional changes in myeloid and lymphocyte populations in the tumor microenvironment, enhancing the activation and effector functions of CD8+ T cells, while reducing T cell exhaustion and dysfunction. Expression of classical genes.[2]
In vivo	ABBV-CLS-484 promotes anti-tumor immunity as a single agent, and when combined with anti-PD-1, results in significant tumor regression, even in models that are resistant to anti-PD-1 treatment, such as 4T1 and EMT6.[3]

Synonyms	AC 484, Osunprotafib, AC484, ABBV-CLS-484
Molecular Weight	385.45
Formula	C17H24FN3O4S
CAS No.	2489404-97-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56.2 mg/mL (145.9 mM), Sonication is recommended.

References and Literature

1. Philip R, et al. Protein tyrosine phosphatase inhibitors and methods of use thereof. WO2022056281A1. 2. Arvin Iracheta-Vellve, et al. Targeting the immune checkpoint PTPN2 with ABBV-CLS-484 inflames the tumor microenvironment and unleashes potent CD8+ T cell immunity. Cancer Res (2022) 82 (12_Supplement): 606. 3. Christina K, et al. ABBV-CLS-484: An active site PTPN2/N1 inhibitor that augments the immune response and sensitizes tumors to immune-mediated killing. Cancer Res (2022) 82 (12_Supplement): ND06. 4. Baumgartner C K, et al. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity[J]. Nature, 2023: 1-13.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Clinical Compound Library

Related Products

Related compounds with same targets

Tegeprotafib TPI-1 (Rac)-LB-100 PROTAC PTPN2 degrader-2 Bis(maltolato)oxovanadium(IV) LMPTP INHIBITOR 1 hydrochloride BCI NSC 65809

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Osunprotafib 2489404-97-7 Metabolism Phosphatase AC 484 ABBV-CLS484 AC-484 ABBV-CLS 484 AC484 ABBV-CLS-484 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.