Anti-C1s Antibody (6O90)

Name: Anti-C1s Antibody (6O90)
Brand: TargetMol
SKU: TMAY-00484
Rating: 4.5 (1 reviews)

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Catalog No. TMAY-00484

Alias FLJ44757, complement component 1, s subcomponent, C1s

Anti-C1s Antibody (6O90) is a Rabbit antibody targeting C1s. Anti-C1s Antibody (6O90) can be used in ELISA.

Anti-C1s Antibody (6O90)

😃Good

Catalog No. TMAY-00484Alias FLJ44757, complement component 1, s subcomponent, C1s

Anti-C1s Antibody (6O90) is a Rabbit antibody targeting C1s. Anti-C1s Antibody (6O90) can be used in ELISA.

Pack Size	Price	Availability	Quantity
100 μL	$268	7-10 days

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Instruction Manual of Detection Antibody

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Product Introduction

Bioactivity

Description	Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human
Alias	FLJ44757, complement component 1, s subcomponent, C1s
Ig Type	Rabbit IgG
Clone	6O90
Reactivity	Human
Application	ELISA
Recommended Dose	ELISA: 1:5000-1:10000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human Complement C1s (rh Complement C1s; TMPY-06585; NP_001725.1; Met 1-Asp 688).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complement, share similar overall structural organizations featuring five nonenzymic protein modules (two CUB modules surrounding a single EGF module, and a pair of CCP modules) followed by a serine protease domain. Besides highly specific proteolytic activities, both proteases exhibit interaction properties associated with their N-terminal regions. In contrast, C1r and C1s widely differ from each other by their glycosylation patterns: both proteins contain Asn-linked carbohydrates, but four glycosylation sites are present on C1r, and only two on C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. Like other complement serine proteases C1s has restricted substrate specificity and it is engaged into specific interactions with other subcomponents of the complement system. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human Complement C1s protein (TMPY-06585)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc