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Anti-CRABP2 Antibody-PE (6M932)
🥰Excellent
Catalog No. TMAY-01744P
Anti-CRABP2 Antibody-PE (6M932) is a PE-conjugated Mouse antibody targeting CRABP2. Anti-CRABP2 Antibody-PE (6M932) can be used in FCM.
Anti-CRABP2 Antibody-PE (6M932)
Anti-CRABP2 Antibody-PE (6M932)
🥰Excellent
Catalog No. TMAY-01744P
Anti-CRABP2 Antibody-PE (6M932) is a PE-conjugated Mouse antibody targeting CRABP2. Anti-CRABP2 Antibody-PE (6M932) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CRABP2 Antibody-PE (6M932) is a PE-conjugated Mouse antibody targeting CRABP2. Anti-CRABP2 Antibody-PE (6M932) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6M932 |
| Reactivity | Human |
| Verified Activity | Profile of anti-CRABP2 reactivity on MCF-7 cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CRABP2 (rh CRABP2; TMPY-01549; NP_001869.1; Pro2-Glu138) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human CRABP2 protein (TMPY-01549) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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