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COX-2-IN-2

Name: COX-2-IN-2
Brand: TargetMol
SKU: T10032
Price: 175 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10032Cas No. 134729-13-8

COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.

COX-2-IN-2

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Purity: 97.62%

Catalog No. T10032Cas No. 134729-13-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$175	In Stock	In Stock
5 mg	$438	In Stock	In Stock
10 mg	$703	In Stock	In Stock
25 mg	$1,400	In Stock	In Stock
50 mg	$2,230	In Stock	In Stock
100 mg	$2,960	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$446	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.62%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.
Targets&IC50	COX-2:240 nM
In vitro	COX-2-IN-2 demonstrates no inhibition of COX-1, even at a concentration of 100μM[1].
In vivo	COX-2-IN-2 exhibits oral ED50 values of 0.030 mg/kg for adjuvant-induced arthritis and 0.47 mg/kg for collagen-induced arthritis, with an ED30 of 7.4 mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay, demonstrating good analgesic activity and no ulcerogenicity[1].

Chemical Properties

Molecular Weight	341.36
Formula	C₁₇H₁₂FN₃O₂S
Cas No.	134729-13-8
Smiles	C(#N)C=1C=C(N(N1)C2=CC=C(F)C=C2)C3=CC=C(S(C)(=O)=O)C=C3
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (439.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9295 mL	14.6473 mL	29.2946 mL	146.4729 mL
5 mM	0.5859 mL	2.9295 mL	5.8589 mL	29.2946 mL
10 mM	0.2929 mL	1.4647 mL	2.9295 mL	14.6473 mL
20 mM	0.1465 mL	0.7324 mL	1.4647 mL	7.3236 mL
50 mM	0.0586 mL	0.2929 mL	0.5859 mL	2.9295 mL
100 mM	0.0293 mL	0.1465 mL	0.2929 mL	1.4647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc