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L-(+)-Arabinose

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Catalog No. T13752Cas No. 5328-37-0

L-(+)-Arabinose selectively inhibits intestinal sucrase in a non-competitive manner, thereby preventing glucose elevation induced by sucrose intake.

L-(+)-Arabinose

L-(+)-Arabinose

😃Good
Purity: 99.94%
Catalog No. T13752Cas No. 5328-37-0
L-(+)-Arabinose selectively inhibits intestinal sucrase in a non-competitive manner, thereby preventing glucose elevation induced by sucrose intake.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 g$30In StockIn Stock
2 g$40In StockIn Stock
5 g$64-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
L-(+)-Arabinose selectively inhibits intestinal sucrase in a non-competitive manner, thereby preventing glucose elevation induced by sucrose intake.
In vitro
L-(+)-Arabinose is associated with ribose-5-phosphate isomerase deficiency, an inborn metabolic error[1]. It selectively inhibits intestinal sucrase in a noncompetitive manner, thereby suppressing the increase in plasma glucose following sucrose consumption[1].
In vivo
L-(+)-Arabinose feeding reduced the weights of epididymal adipose tissue in rats. Moreover, plasma insulin and triacylglycerol concentrations were significantly reduced by dietary L-(+)-Arabinose[1]. L-(+)-Arabinose suppresses gluconeogenesis through modulating AMP-activated protein kinase in metabolic disorder mice[2].
Chemical Properties
Molecular Weight150.13
FormulaC5H10O5
Cas No.5328-37-0
Smiles[C@H]([C@H](CO)O)([C@H](C=O)O)O
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (399.65 mM), Sonication is recommended.
H2O: 400 mg/mL (2664.36 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.66 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM6.6609 mL33.3045 mL66.6089 mL333.0447 mL
5 mM1.3322 mL6.6609 mL13.3218 mL66.6089 mL
10 mM0.6661 mL3.3304 mL6.6609 mL33.3045 mL
20 mM0.3330 mL1.6652 mL3.3304 mL16.6522 mL
50 mM0.1332 mL0.6661 mL1.3322 mL6.6609 mL
100 mM0.0666 mL0.3330 mL0.6661 mL3.3304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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