Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

BSH-IN-1

🥰Excellent
Catalog No. T10623Cas No. 2553217-91-5

BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH).

BSH-IN-1

BSH-IN-1

🥰Excellent
Purity: 99.89%
Catalog No. T10623Cas No. 2553217-91-5
BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$118In StockIn Stock
5 mg$297In StockIn Stock
10 mg$469In StockIn Stock
25 mg$777In StockIn Stock
50 mg$1,070In StockIn Stock
100 mg$1,490In StockIn Stock
1 mL x 10 mM (in DMSO)$327In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.89%
Contact us for more batch information

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity
Description
BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH).
In vitro
BSH-IN-1 also inhibits BSH activity in growing cultures of Gram-negative (Bacteroides fragilis ATCC 25285, B. theta VPI-5482, and Bacteroides vulgatus ATCC 8482) and Gram-positive (C. perfringens ATCC 13124, Lactobacillus plantarum WCFS1, and Bifidobacterium adolescentis L2–32) bacteria. BSH-IN-1 also is a potent BSH inhibitor in growing bacterial cultures with IC50s of 237 nM and 1070 nM for B. adolescentis and B. theta, respectively.
In vivo
In C57BL/6 mice, BSH-IN-1 (10 mg/kg; a single dose; gavage）inhibits BSH activity and can be gut-restricted.
Chemical Properties
Molecular Weight408.59
FormulaC25H41FO3
Cas No.2553217-91-5
Smiles[H][C@]1([C@@H](CCC(CF)=O)C)CC[C@]2([C@@]3([C@@H](C[C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H]
Relative Density.1.097 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (97.9 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.89 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4474 mL12.2372 mL24.4744 mL122.3721 mL
5 mM0.4895 mL2.4474 mL4.8949 mL24.4744 mL
10 mM0.2447 mL1.2237 mL2.4474 mL12.2372 mL
20 mM0.1224 mL0.6119 mL1.2237 mL6.1186 mL
50 mM0.0489 mL0.2447 mL0.4895 mL2.4474 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PotassiumChannelPotassium ChannelBSH-IN-1BSHIN1BSH IN 1Bile salt hydrolase (BSH)
Related Tags: buy BSH-IN-1 | purchase BSH-IN-1 | BSH-IN-1 cost | order BSH-IN-1 | BSH-IN-1 chemical structure | BSH-IN-1 in vivo | BSH-IN-1 in vitro | BSH-IN-1 formula | BSH-IN-1 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.