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Abacavir hydroxyacetate

Name: Abacavir hydroxyacetate
Brand: TargetMol
SKU: T1267L
Rating: 4.5 (1 reviews)

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Catalog No. T1267LCas No. 1446418-48-9

Alias Abacavirhydroxyacetate

Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.

Abacavir hydroxyacetate

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Purity: 98.29%

Catalog No. T1267LAlias AbacavirhydroxyacetateCas No. 1446418-48-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	Inquiry	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.29%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.
In vivo	In 6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue, Abacavir hydroxyacetate (10 and 20 mg/kg; oral gavage; 10-20 mg/kg once) decreases the concentration of PRINS and IL-20, and reduces the lesion area of the skin, showing a better effect than methotrexate in controlling psoriasis[1].
Synonyms	Abacavirhydroxyacetate

Chemical Properties

Molecular Weight	344.37
Formula	C₁₆H₂₀N₆O₃
Cas No.	1446418-48-9
Smiles	Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](COC(=O)CO)C=C3)c2n1
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (232.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9039 mL	14.5193 mL	29.0385 mL	145.1927 mL
5 mM	0.5808 mL	2.9039 mL	5.8077 mL	29.0385 mL
10 mM	0.2904 mL	1.4519 mL	2.9039 mL	14.5193 mL
20 mM	0.1452 mL	0.7260 mL	1.4519 mL	7.2596 mL
50 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4519 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc