HER2/ERBB2 Protein, Rat, Recombinant

Name: HER2/ERBB2 Protein, Rat, Recombinant
Brand: TargetMol
SKU: TMPY-01942
Rating: 4.5 (1 reviews)

(Synonyms: erb-b2 receptor tyrosine kinase 2, EGFR2) Copy Product Info

Synonyms: erb-b2 receptor tyrosine kinase 2, EGFR2

Catalog No. TMPY-01942 Copy Product Info

HER2/ERBB2 Protein, Rat, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70.6 kDa and the accession number is AAH61863.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$129	7-10 days	7-10 days
10 µg	$208	7-10 days	7-10 days
20 µg	$345	7-10 days	7-10 days
50 µg	$812	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	HER2/ERBB2 Protein, Rat, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70.6 kDa and the accession number is AAH61863.1.
Species	Rat
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	AAH61863.1
Construction	A DNA sequence encoding the rat ErbB2 (AAH61863.1) extracellular domain (Met 4-Thr 656) was expressed and purified, with seven additional amino acids (ALEVLFQ) at the C-terminus. Predicted N terminal: Thr 26
Protein Purity	> 92 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	erb-b2 receptor tyrosine kinase 2, EGFR2
Research Background	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

70.6 kDa (predicted); 95-105 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.