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Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody

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Catalog No. TMAB-11523

Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody is a Rabbit antibody targeting plasma kallikrein B1 heavy chain. Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody can be used in WB.

Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody

Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody

😃Good
Catalog No. TMAB-11523
Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody is a Rabbit antibody targeting plasma kallikrein B1 heavy chain. Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody is a Rabbit antibody targeting plasma kallikrein B1 heavy chain. Anti-plasma kallikrein B1 heavy chain Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Cow)
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundPlasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human plasma kallikrein B1 heavy chain
Antigen Species
Human
Gene Name
KLKB1
Gene ID
Protein Name
Plasma kallikrein
Uniprot ID
Function
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Chemical Properties
Molecular WeightTheoretical: 41 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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