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AMG 837
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Catalog No. T14216Cas No. 865231-46-5
Alias AMG837
AMG 837 is a novel and potent GPR40/FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents.
AMG 837
😃Good
Catalog No. T14216Alias AMG837Cas No. 865231-46-5
AMG 837 is a novel and potent GPR40/FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $133 | 35 days | 35 days | |
| 5 mg | $420 | 35 days | 35 days | |
| 10 mg | $772 | 35 days | 35 days | |
| 25 mg | $1,750 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | AMG 837 is a novel and potent GPR40/FFA1 agonist that enhances insulin secretion and lowers blood glucose levels in rodents. |
| In vivo | Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. [2] |
| Synonyms | AMG837 |
| Molecular Weight | 438.44 |
| Formula | C26H21F3O3 |
| Cas No. | 865231-46-5 |
| Smiles | C(OC1=CC=C([C@H](CC(O)=O)C#CC)C=C1)C=2C=C(C=CC2)C3=CC=C(C(F)(F)F)C=C3 |
| Relative Density. | 1.251 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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