Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in combination with progestins in the study of endometriosis.

Norethindrone acetate effectively relieves dysmenorrhea and noncyclic pelvic pain.[1]
Norethindrone acetate as a standalone treatment option demonstrates excellent tolerability and efficacy in managing pain and bleeding associated with all stages of endometriosis.[2]
Experimental studies indicate that norethindrone acetate exhibits low acute toxicity in animals. Administration of norethindrone acetate alone to rodents at doses several times higher than those used in humans does not result in treatment-related mortality, hematological changes, behavioral alterations, or organ pathology.[3]
Administration of norethindrone acetate leads to significant and proportional reductions in the concentrations of triglycerides, cholesterol, and phospholipids in plasma lipoproteins with a density <1.006 in rats fed a high carbohydrate diet.[4]
Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides in isolated hepatocytes obtained from fed rats.[4]