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Norethindrone acetate

Catalog No. T40598 CAS 51-98-9

Synonyms: 19-Norethindroneacetate

Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in combination with progestins in the study of endometriosis.

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Norethindrone acetate Chemical Structure

Norethindrone acetate, CAS 51-98-9

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Purity: 99.4%

Biological Description

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Description

In vivo

Norethindrone acetate effectively relieves dysmenorrhea and noncyclic pelvic pain.[1]
Norethindrone acetate as a standalone treatment option demonstrates excellent tolerability and efficacy in managing pain and bleeding associated with all stages of endometriosis.[2]
Experimental studies indicate that norethindrone acetate exhibits low acute toxicity in animals. Administration of norethindrone acetate alone to rodents at doses several times higher than those used in humans does not result in treatment-related mortality, hematological changes, behavioral alterations, or organ pathology.[3]
Administration of norethindrone acetate leads to significant and proportional reductions in the concentrations of triglycerides, cholesterol, and phospholipids in plasma lipoproteins with a density <1.006 in rats fed a high carbohydrate diet.[4]
Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides in isolated hepatocytes obtained from fed rats.[4]

Synonyms	19-Norethindroneacetate
Molecular Weight	340.46
Formula	C22H28O3
CAS No.	51-98-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 0.6 mg/mL (1.8 mM ), Sonication is recommended.

DMSO: 90.0 mg/mL (264.3 mM)

References and Literature

1. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 ; 43(1):24-27. 2. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 ; 25(2):105-108. 3. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 ; 34(1):53-61. 4. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 ; 46(1):41-48.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library EMA Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Nuclear Receptor Compound Library FDA-Approved Drug Library Approved Drug Library Bioactive Compound Library

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Related compounds with same targets

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Keywords

Norethindrone acetate 51-98-9 Endocrinology/Hormones Others Estrogen Receptor/ERR Progesterone Receptor 19-Norethindroneacetate Norethindrone Acetate inhibitor inhibit

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