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YM 511
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Catalog No. T23549Cas No. 148869-05-0
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly inhibits production of other steroid hormones. YM 511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.
YM 511
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Purity: 99.96%
Catalog No. T23549Cas No. 148869-05-0
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly inhibits production of other steroid hormones. YM 511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | In Stock | In Stock | |
| 5 mg | $77 | In Stock | In Stock | |
| 10 mg | $128 | In Stock | In Stock | |
| 25 mg | $273 | In Stock | In Stock | |
| 50 mg | $437 | In Stock | In Stock | |
| 100 mg | $592 | - | In Stock | |
| 200 mg | $783 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.96%
Appearance:Solid
Color:White
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Product Introduction
YM 511 AI Summary
YM 511 demonstrates a wide range of bioactivities, most notably as a potent inhibitor of aromatase with an IC50 value of 0.5 nM in human JEG-3 cells, highlighting its potential use in hormone-related conditions like breast cancer by reducing estrogen production. It also inhibits the binding of [1-beta-3H]-androstenedione to Cytochrome P450 19A1 in JEG-3 cells, suggesting anti-cancer or anti-hormonal properties. In vivo studies in Wistar rats show significant aromatase inhibition at a dose of 10 mg/kg. Additionally, YM 511 exhibits strong inhibitory activity against steroid sulfatase in Wistar rat liver and placental microsomes. It also displays antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 cells at a concentration of 10 µM and showing moderate inhibition of the SARS-CoV-2 3CL-Pro protease. Moreover, YM 511 demonstrates inhibitory activity toward human HDAC6 in enzymatic assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly inhibits production of other steroid hormones. YM 511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones. |
| Molecular Weight | 354.2 |
| Formula | C16H12BrN5 |
| Cas No. | 148869-05-0 |
| Smiles | N(CC1=CC=C(Br)C=C1)(C2=CC=C(C#N)C=C2)N3C=NN=C3 |
| Relative Density. | 1.44g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 8.86 mg/mL, Sonication is recommended. DMSO: 250 mg/mL (705.82 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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