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Anti-4E-BP1 Monoclonal Antibody (9P792)
(Synonyms: PHAS-I, MGC4316, EIF4EBP1, BP-1, 4E-BP1, 4EBP1) Copy Product Info
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Synonyms: PHAS-I, MGC4316, EIF4EBP1, BP-1, 4E-BP1, 4EBP1
Catalog No. TMAT-0002 Copy Product Info
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Anti-4E-BP1 Monoclonal Antibody (9P792) is a Mouse antibody targeting 4E-BP1. Anti-4E-BP1 Monoclonal Antibody (9P792) can be used in IHC.
Anti-4E-BP1 Monoclonal Antibody
(9P792)
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Product Introduction
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| Description | Anti-4E-BP1 Monoclonal Antibody (9P792) is a Mouse antibody targeting 4E-BP1. Anti-4E-BP1 Monoclonal Antibody (9P792) can be used in IHC. |
| Synonyms | PHAS-I, MGC4316, EIF4EBP1, BP-1, 4E-BP1, 4EBP1 |
| Ig Type | IgG1 |
| Clone | 9P792 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | 4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of 4E-BP1 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | EIF4EBP1 |
| Gene ID | |
| Protein Name | Eukaryotic translation initiation factor 4E-binding protein 1 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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