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VAS 3947

Name: VAS 3947
Brand: TargetMol
SKU: T29097
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29097Cas No. 869853-70-3

Alias VA-S3947, VAS3947, VA S3947

VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.

VAS 3947

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Purity: 98.44%

Catalog No. T29097Alias VA-S3947, VAS3947, VA S3947Cas No. 869853-70-3

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$98	In Stock
10 mg	$178	In Stock
25 mg	$311	In Stock
50 mg	$447	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Purity:98.44%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX activity.
Targets&IC50	ROS:12 µM, THP-1 cells:4.9µM, MV-4-11 cells:2.6±0.6µM
In vitro	VAS 3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.[1] VAS 3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection.[4] VAS 3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3.[5]
Synonyms	VA-S3947, VAS3947, VA S3947

Chemical Properties

Molecular Weight	310.33
Formula	C₁₄H₁₀N₆OS
Cas No.	869853-70-3
Smiles	C(c1ccccc1)n1nnc2c(Sc3ncco3)ncnc12
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (290.0 mM ), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2224 mL	16.1119 mL	32.2238 mL	161.1188 mL
5 mM	0.6445 mL	3.2224 mL	6.4448 mL	32.2238 mL
10 mM	0.3222 mL	1.6112 mL	3.2224 mL	16.1119 mL
20 mM	0.1611 mL	0.8056 mL	1.6112 mL	8.0559 mL
50 mM	0.0644 mL	0.3222 mL	0.6445 mL	3.2224 mL
100 mM	0.0322 mL	0.1611 mL	0.3222 mL	1.6112 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc