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Synonyms: ML-1, Interleukin-17F, Interleukin-17A, IL24, IL-17F, IL-17A, IL-17, CTLA-8


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $74 | 7-10 days | 7-10 days | |
| 10 µg | $113 | 7-10 days | 7-10 days | |
| 20 µg | $175 | 7-10 days | 7-10 days | |
| 50 µg | $316 | 7-10 days | 7-10 days | |
| 100 µg | $490 | 7-10 days | 7-10 days | |
| 200 µg | $793 | 7-10 days | 7-10 days | |
| 500 µg | $1,470 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Mouse IL-17A&F, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Mouse IL-17R alpha, hFc Tag with the EC50 of 6.9 ng/ml determined by ELISA (QC Test). |
| Description | IL-17A & IL-17F Heterodimer Protein, Mouse, Recombinant (Strep-II & His) is expressed in HEK293 Cells. The accession number is Q62386(IL-17A)&Q7TNI7-1(IL-17F). |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | N-Strep-II, N-His |
| Accession Number | Q62386(IL-17A)&Q7TNI7-1(IL-17F) |
| Construction | Ala26-Ala158 (IL-17A) and Arg29-Ala161 (IL-17F) |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| Endotoxin | < 0.1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | ML-1, Interleukin-17F, Interleukin-17A, IL24, IL-17F, IL-17A, IL-17, CTLA-8 |
| Research Background | Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. |
| Molecular Weight | 16.01 kDa (IL-17A) and 15.98 kDa (IL-17F) (Predicted); 13-23 kDa and 25-35 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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