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Hydroxy Dimetridazole

Name: Hydroxy Dimetridazole
Brand: TargetMol
SKU: T37514
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37514Cas No. 936-05-0

Hydroxy Dimetridazole is a hydroxy metabolite of Dimetridazole which combats protozoan infections.

Hydroxy Dimetridazole

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Purity: 99.85%

Catalog No. T37514Cas No. 936-05-0

Hydroxy Dimetridazole is a hydroxy metabolite of Dimetridazole which combats protozoan infections.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$48	-	In Stock
1 g	$78	-	In Stock
2 g	$115	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Hydroxy Dimetridazole AI Summary

Hydroxy Dimetridazole has a logP value of -0.03, indicating low lipid solubility and limited interaction with the stationary phase. The compound demonstrates biliary excretion properties in rats, with an increasing percentage of excretion over a period of 6 hours following intravenous administration, reaching 37.77% in bile samples collected within this timeframe. In vitro, Hydroxy Dimetridazole exhibits anti-trichomonal activity against Trichomonas foetus-Ortho strain-2 with an ED50 of 1.6 µg/ml and shows mutagenicity at 16.0% relative to Ronidazole. Furthermore, it has a safety index of 1.6. Hydroxy Dimetridazole primarily undergoes renal excretion, with increasing amounts detected in urine over a 72-hour period, suggesting high renal clearance and efficient elimination from the body..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Hydroxy Dimetridazole is a hydroxy metabolite of Dimetridazole which combats protozoan infections.

Chemical Properties

Molecular Weight	157.13
Formula	C₅H₇N₃O₃
Cas No.	936-05-0
Smiles	Cn1c(CO)ncc1[N+]([O-])=O
Relative Density.	1.4890 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 30 mg/mL (190.92 mM), Sonication is recommended.

DMSO: 50 mg/mL (318.21 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (6.36 mM), Sonication is recommended.

Ethanol: 3 mg/mL (19.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

PBS (pH 7.2)/Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3642 mL	31.8208 mL	63.6416 mL	318.2079 mL
5 mM	1.2728 mL	6.3642 mL	12.7283 mL	63.6416 mL

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.6364 mL	3.1821 mL	6.3642 mL	31.8208 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.3182 mL	1.5910 mL	3.1821 mL	15.9104 mL
50 mM	0.1273 mL	0.6364 mL	1.2728 mL	6.3642 mL
100 mM	0.0636 mL	0.3182 mL	0.6364 mL	3.1821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc