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NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

  • 2,4-Diamino-6-hydroxypyrimidine
    T746156-06-4
    2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
    • $41
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  • L-NAME hydrochloride
    T657051298-62-5
    L-NAME hydrochloride (L-NAME HCl), a cell-permeable NO synthase inhibitor, displays Ki values of 4.4 μM, 15 nM, and 39 nM, for iNOS (mouse) , nNOS (bovine) , and eNOS (human), respectively.
    • $46
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  • Mifepristone
    T110284371-65-3
    Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
    • $37
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  • Ethyl cinnamate
    TN1624103-36-6
    Ethyl cinnamate has antifungal, and vasorelaxant effects. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction. Ethyl cinnamate can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 mM and 0.38 mM.
    • $30
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  • Hulupinic acid
    TN42281891-42-5
    Hulupinic acid is the main oxidation product of hop acid, which may inhibit the production of NO in macrophages RAW 264.7 cells.
    • $143
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  • AVE-9488
    T30219291756-32-6
    AVE-9488 is a novel endothelial NO synthase (eNOS) enhancer that upregulates eNOS expression, induces NO production, and may ameliorate portal hypertension.
    • $293
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  • Anhydronotoptol
    TN698588206-51-3
    Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangwu, is a potent inhibitor of nitric oxide production, inhibiting LPS-induced NO production in RAW 264.7 cells with an IC50 value of 36.6 μM.
    • $340
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  • FK-330 dihydrate
    T68879682813-92-9In house
    FK-330 dihydrate(FR-260330 dihydrate) is a novel orally active inducible nitric oxide synthase inhibitor with potential anticancer and antitumor activity to prevent ischemia and reperfusion injury in rat liver transplantation.
    • $397
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  • 6-Methoxynaringenin
    TN317694942-49-1In house
    6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.
    • $598
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  • Camstatin acetate
    TP2057L
    Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calmodulin-binding IQ motif of PEP-19.
    • $148
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  • NG-Nitroarginine methyl ester
    T2586550903-99-6
    NG-Nitroarginine methyl ester (ω-Nitroarginine methyl) is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.
    • $148
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  • Calycanthoside
    TN1463483-91-0
    Calycanthoside (Isofraxidin 7-O-beta-D-Glucoside) is a natural compound isolated from Angelica tenuissima. Calycanthoside shows anti-inflammatory and antibacterial effects.
    • $106
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  • Hydrangenol
    TN4234480-47-7In house
    Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.
    • $139
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  • Topoisomerase II inhibitor 14
    T77650305343-00-4
    Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.Topoisomerase II inhibitor 14 reduces the amount of GSH, MDA and NO. Topoisomerase II inhibitor 14 reduces the amount of GSH, MDA and NO.
    • $158
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  • Moracin C
    TN194969120-06-5In house
    Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells.
    • $198
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  • MSU-42011
    T774992456434-36-7In house
    MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated antitumor activity in a kras-driven mouse model of lung cancer.MSU-42011 is an effective therapy for the treatment of preclinical krasdriven lung cancer and has immunomodulatory activity.
    • $41
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  • Chondroitin sulfate
    T29809007-28-7
    Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition
    • $47
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  • 1400W dihydrochloride
    T3491214358-33-5
    1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) is a highly effective and specific inhibitor of inducible NOS2 (iNOS).
    • $43
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  • Isoquercetin
    T5S0754482-35-9
    1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt/β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .
    • $43
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  • Methylene Blue
    T688861-73-4
    Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
    • $30
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  • Aminoguanidine hydrochloride
    T03581937-19-5
    Aminoguanidine hydrochloride (Hydrazinecarboximidamide) is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
    • $36
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  • L-Arginine
    T3S036474-79-3
    1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway. 4. A combination of oral L-citrulline and L-Arginine effectively and rapidly augments NO-dependent responses at the acute stage.
    • $32
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  • ETHYL CAFFEATE
    T5681102-37-4
    Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related signaling, including IFN-γ, T-bet, STAT1, and STAT4.
    • $41
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  • AChE-IN-3
    T403352713548-95-7
    AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.
    • $44
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  • Escin IB
    T5S138926339-90-2
    Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.
    • $64
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  • Kazinol B
    T2023299624-27-8
    Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activating the insulin-Akt signalling pathway and AMPK, which enhances glucose uptake.Kazinol B stimulates gene expression and secretion of adiponectin and can be used to study diabetes.
    • $1,760
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  • 3,4-O-Isopropylidene-shikimic acid
    TN1238183075-03-8
    3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced by trinitrobenzenesulfonic acid in rats, probably due to antioxidant action.
    • $115
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  • Physalin L
    TN1102113146-74-0
    Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
    • $150
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  • Tsugaric acid A
    TN2286174391-64-1
    5-(Hydroxymethyl)uracil is a product of oxidative DNA damage and is capable of enhancing or inhibiting potential epigenetic markers for transcription by bacterial RNA polymerases.
    • $64
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  • Dimaprit dihydrochloride
    T2272423256-33-9
    Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.
    • $48
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  • Resveratroloside
    TN214438963-95-0
    Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
    • $90
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  • Grasshopper ketone
    TN538741703-38-2
    Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation.
    • $1,698
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  • GW274150 dihydrochloride
    T82251438542-17-7
    GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 μM and Kd of 40 nM for human iNOS, and an ED50 of 1.15 μM for rat iNOS. It demonstrates reduced effectiveness against endothelial NOS (eNOS) and neuronal NOS (nNOS) in both species. The compound has been shown to confer protective effects in acute lung injury inflammation models [1] [2] [3].
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  • 2-Iminobiotin
    T720613395-35-2
    2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).
    • $78
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  • 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
    TN1109168293-14-9
    3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.
    • $100
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  • Rutaevin
    TN216733237-37-5
    Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.
    • $287
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  • Kuwanon A
    TQ030162949-77-3
    Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
    • $49
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  • Cnidicin
    TN151614348-21-1
    Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor
    • $153
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  • 2-Iminobiotin hydrobromide
    T7206L76985-52-9
    2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).
    • $29
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  • 2-Thiouracil
    T1310141-90-2
    2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
    • $29
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  • (E)-Ferulic acid methyl ester
    T3S000622329-76-6
    (E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first time in medicinal plant S. tuberosa. (E)-Ferulic acid methyl ester has promising anthelmintic activity against Haemonchus contortus.
    • $50
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  • Epimagnolin B
    TN10091134188-26-3
    Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.
    • $152
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  • Nitro blue tetrazolium chloride
    T19032298-83-9
    Nitro blue tetrazolium chloride (NBT) is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 M). A well-known scavenger of superoxide anions.Nitro blue tetrazolium chloride, a substrate for dehydrogenases, is used with the alkaline phosphatase substrate BCIP in western blotting and immunohistological staining procedures.
    • $42
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  • Multiflorin B
    T8000052657-01-9
    Multiflorin B (compound 5), a kaempferol glycoside, can be extracted from the root of Neocheiropteris palmatopedata. This compound demonstrates the ability to inhibit nitric oxide production, achieving a 52% inhibition at a concentration of 20 μg/ml [1].
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  • Irisflorentin
    T6S166541743-73-1
    1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechanism in LPS-activated RAW 264.7 macr
    • $60
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  • NG,NG-dimethyl-L-Arginine dihydrochloride
    T21546220805-22-1
    NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
    • $43
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  • Dactylorhin A
    TN1546256459-34-4
    Dactylorhin A, a succinate derivative ester isolated from the rhizomes of Gymnadenia conopsea, demonstrates a moderate inhibitory effect on nitric oxide (NO) production in RAW 264.7 macrophage cells.
    • $47
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  • Asperuloside
    T384714259-45-1
    Asperuloside (Asperulosid) has anti-inflammatory activity.
    • $55
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  • Obtucarbamate A
    TN20036935-99-5
    Obtucarbamate A isolated from Disporum cantoniense has antitussive activity.It has antitussive activity, it exhibits significant inhibitory effect against neuroinflammation with the IC50 value of 10.57 μM .
    • $83
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  • Piceatannol 3'-O-glucoside
    T3S040194356-26-0
    Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.
    • $64
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