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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.

Filter HomeSignaling PathwaysImmunology/InflammationNO Synthase

5-O-Caffeoylshikimic acid

TN129573263-62-4

5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.

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Glycyrrhisoflavone

TN1705116709-70-7

Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.

$119

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Atranorin

TN1413479-20-9

Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotective effects on cells under oxidative

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Mifepristone

T110284371-65-3

Mifepristone (C-1073) is a progesterone-receptor (IC50=0.2 nM) and glucocorticoid-receptor antagonist (IC50=2.6 nM). Mifepristone is used to terminate pregnancy, treat uterine fibroids, and treat endometriosis.

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L-Arginine

T3S036474-79-3

L-Arginine (L-Arg) is a substrate of endothelial nitric oxide synthase (eNOS). L-Arginine is transported to vascular smooth muscle cells via a family of cationic amino acid transporters and is metabolized to nitric oxide, polyamines, or L-proline. L-Arginine is a potent vasodilator and can be used to induce experimental acute pancreatitis.

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Glabrol

TN169159870-65-4

5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.

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Andropanolide

TQ0073869807-57-8

Andropanolide is a dipterocarbon from Andrographis paniculata with anti-HIV, antimalarial and anticancer activities and inhibits Lipopolysaccharides (LPS)-stimulated overproduction of nitric oxide (NO) in RAW264.7 macrophages.

$155

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Ginsenoside C-K

T381139262-14-1

Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

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Nitro blue tetrazolium chloride

T19032298-83-9

Nitro blue tetrazolium chloride (NBT), an NADPH-diaphorase substrate (IC50 = 3-4 M) and well-known scavenger of superoxide anions, competitively inhibits nitric oxide synthase. Additionally, NBT, as a substrate for dehydrogenases, is used with the alkaline phosphatase substrate BCIP in western blotting and immunohistological staining procedures.

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Isosorbide dinitrate

T147987-33-2

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

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Taraxasterol

T37701059-14-9

Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity.

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Madecassic acid

T275818449-41-7

Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.

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Hydrangenol

TN4234480-47-7In house

Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.

$139

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NG,NG-dimethyl-L-Arginine dihydrochloride

T21546220805-22-1

NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].

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7-Ethoxyresorufin

T215075725-91-7

7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate and competitive inhibitor of cytochrome P450, particularly CYP1A1.

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Chondroitin sulfate

T29809007-28-7

Chondroitin sulfate (Chonsurid) is extracted from shark bone;Store the product in sealed, cool and dry condition

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26-Deoxyactein

TN1222264624-38-6

23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.

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L-NAME hydrochloride

T657051298-62-5

L-NAME hydrochloride is an inhibitor of nitric oxide synthase (NOS) with an IC₅₀ of 70 μM, and it can be used to induce hypertension and kidney injury models.

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NOC-5

T35969146724-82-5

NOC-5 is an NO donor that induces airway relaxation and concentration-dependently triggers 10 μM DAF-2 fluorescence.

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Escin IB

T5S138926339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

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DETA NONOate

T36033146724-94-9

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infected wounds.

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Ginsenoside Rb3

T391868406-26-8

Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA.

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Eupatolide

TN40386750-25-0

Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.

$800

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Asymmetric dimethylarginine

T768230315-93-6

Asymmetric dimethylarginine [an endogenous inhibitor of nitric oxide synthase (NOS)], is a compound that inhibits the enzyme responsible for producing nitric oxide.

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