Shopping Cart

Your shopping cart is currently empty

Pramiracetam

Name: Pramiracetam
Brand: TargetMol
SKU: T0183
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T0183Cas No. 68497-62-1

Alias CI-879

Pramiracetam (CI-879), derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic brain wounds. Pramiracetam was also potent in the therapy of cognitive disorders of traumatic origins and cerebrovascular.

Pramiracetam

Copy Product Info

🥰Excellent

Purity: 99.94%

Catalog No. T0183Alias CI-879Cas No. 68497-62-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$38	In Stock	In Stock
100 mg	$58	In Stock	In Stock
200 mg	$93	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Pramiracetam AI Summary

Pramiracetam demonstrates the ability to reverse electroconvulsive shock-induced amnesia in mice, with the percentage of amnesia reversal ranging from 0.0% at 0.63 mg/kg to 96.0% at 5 mg/kg. However, the effectiveness decreases at a dose of 20.0 mg/kg and significantly drops at 80.0 mg/kg. Additionally, this compound shows bioactivity in inhibiting Plasmodium falciparum (DD2) proliferation with a potency of 7492.9 nM. In terms of antiviral activity, Pramiracetam has demonstrated low to negligible effectiveness against SARS-CoV-2 induced cytotoxicity in various assays and cell models, including Caco-2 and VERO-6 cells, with inhibition percentages ranging from -0.12% to a maximum IC50 value greater than 20000.0 nM. The compound also inhibits the SARS-CoV-2 3CL-Pro protease with varying inhibition percentages. Moreover, it exhibits inhibitory activity on the human HDAC6 enzyme, decreasing enzyme activity by 31.7% with a commercial peptide substrate and by 8.52% with a custom peptide substrate. However, the compound showed no significant bioactivity in assays conducted for various other targets, with all AC50 values being greater than 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pramiracetam (CI-879), derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic brain wounds. Pramiracetam was also potent in the therapy of cognitive disorders of traumatic origins and cerebrovascular.
Synonyms	CI-879

Chemical Properties

Molecular Weight	269.38
Formula	C₁₄H₂₇N₃O₂
Cas No.	68497-62-1
Smiles	C(C(NCCN(C(C)C)C(C)C)=O)N1C(=O)CCC1
Relative Density.	1.036 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (185.61 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7122 mL	18.5611 mL	37.1223 mL	185.6114 mL
5 mM	0.7424 mL	3.7122 mL	7.4245 mL	37.1223 mL
10 mM	0.3712 mL	1.8561 mL	3.7122 mL	18.5611 mL
20 mM	0.1856 mL	0.9281 mL	1.8561 mL	9.2806 mL
50 mM	0.0742 mL	0.3712 mL	0.7424 mL	3.7122 mL
100 mM	0.0371 mL	0.1856 mL	0.3712 mL	1.8561 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc