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Setomimycin
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Catalog No. T26189Cas No. 69431-87-4
Alias Antibiotic A 39183B, AM-2947, AM2947, AM 2947
Setomimycin is a potent antibiotic compound that inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 12.02 μM, and also exhibits anti-inflammatory, antioxidant, antiproliferative, and antitumor activities, enabling multidisciplinary research spanning antiviral drug discovery, inflammation biology, and cancer pharmacology.
Setomimycin
Copy Product Info😃Good
Catalog No. T26189Alias Antibiotic A 39183B, AM-2947, AM2947, AM 2947Cas No. 69431-87-4
Setomimycin is a potent antibiotic compound that inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 12.02 μM, and also exhibits anti-inflammatory, antioxidant, antiproliferative, and antitumor activities, enabling multidisciplinary research spanning antiviral drug discovery, inflammation biology, and cancer pharmacology.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:Brown
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Product Introduction
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Chemical Properties
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| Description | Setomimycin is a potent antibiotic compound that inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 12.02 μM, and also exhibits anti-inflammatory, antioxidant, antiproliferative, and antitumor activities, enabling multidisciplinary research spanning antiviral drug discovery, inflammation biology, and cancer pharmacology. |
| Targets&IC50 | SARS-CoV-2 Mpro:12.02 μM |
| In vitro | In enzymatic assays, Setomimycin inhibited SARS-CoV-2 Mpro with an IC50 of 12.02 μM. In cellular models, it inhibited NO and cytokine release in LPS-stimulated macrophages (0.01-1 μM), showed antibacterial activity against Gram-positive bacteria (MIC 4-16 μg/mL), and inhibited cancer cell proliferation (IC50 4.57-48 μM) by modulating p-MEK/p-ERK/Bcl-2/Par-4 levels [1]. |
| In vivo | In a 4T1 mouse breast cancer model using BALB/c mice, intraperitoneal (i.p.) administration of Setomimycin (20 mg/kg, every other day) for two weeks reduced primary tumor growth. The treatment resulted in a 76% reduction in tumor weight and a 90.5% reduction in tumor volume compared to the control group [2]. |
| Synonyms | Antibiotic A 39183B, AM-2947, AM2947, AM 2947 |
| Molecular Weight | 580.59 |
| Formula | C34H28O9 |
| Cas No. | 69431-87-4 |
| Smiles | O=C1C=C(C)C(C(=O)C)C2=C1C(O)=C3C(O)=CC=CC3=C2C=4C=5C=CC=C(O)C5C(O)=C6C(=O)CC(O)(C)C(C(=O)C)C64 |
| Relative Density. | 1.31g/cm3 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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