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MF-438

Name: MF-438
Brand: TargetMol
SKU: T16068
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16068Cas No. 921605-87-0

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).

MF-438

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Purity: 99.50%

Catalog No. T16068Cas No. 921605-87-0

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
2 mg	$147	In Stock	In Stock
5 mg	$226	In Stock	In Stock
10 mg	$345	In Stock	In Stock
25 mg	$586	In Stock	In Stock
50 mg	$838	In Stock	In Stock
100 mg	$1,160	In Stock	In Stock
500 mg	$2,320	-	In Stock
1 mL x 10 mM (in DMSO)	$248	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.50%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

MF-438 AI Summary

MF-438 has demonstrated significant oral bioavailability in preclinical models, with 73.0% in mice and 38.0% in rats. It features a moderate half-life of roughly 6 hours in both species. This compound exhibits potent inhibitory activity against stearoyl-CoA desaturase 1 (SCD1), with an IC50 value of 2.3 nM in rat liver microsomes and an ED50 of 1.0 mg/kg in high-carbohydrate diet-fed mice for inhibiting the conversion of [14C]stearic acid to [14C]oleic acid. Additionally, MF-438 shows antidiabetic properties in diet-induced obese C57BL6 mice, improving glucose clearance with an ED50 ranging from 3.0 to 75.0 mg/kg, and modulates lipid metabolism. Its inhibition of SCD activity spans various models, with IC50 values ranging from 2.0 to 157.0 nM, and it demonstrates favorable pharmacokinetic properties with high liver uptake correlate to plasma levels. The compound also impacts body weight gain in diet-induced obese mice. Overall, MF-438 holds potential for therapeutic applications in diabetes and lipid metabolism disorders through effective SCD inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
Targets&IC50	SCD1 (rat):2.3 nM (EC50)

Chemical Properties

Molecular Weight	421.44
Formula	C₁₉H₁₈F₃N₅OS
Cas No.	921605-87-0
Smiles	Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
Relative Density.	1.365 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.4 mg/mL (107.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3728 mL	11.8641 mL	23.7282 mL	118.6409 mL
5 mM	0.4746 mL	2.3728 mL	4.7456 mL	23.7282 mL
10 mM	0.2373 mL	1.1864 mL	2.3728 mL	11.8641 mL
20 mM	0.1186 mL	0.5932 mL	1.1864 mL	5.9320 mL
50 mM	0.0475 mL	0.2373 mL	0.4746 mL	2.3728 mL
100 mM	0.0237 mL	0.1186 mL	0.2373 mL	1.1864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc