M 16209

Name: M 16209
Brand: TargetMol
SKU: T213640
Rating: 4.5 (1 reviews)

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M 16209 is an orally active aldose reductase (AR) inhibitor. It effectively inhibits partially purified aldose reductase from various sources, with IC50 values of 0.12 μM for rat lens AR, 0.24 μM for bovine lens AR, 4.5 μM for bovine kidney AR, 1.2 μM for canine lens AR, and 9.3 μM for human placental AR. M 16209 is applicable in the study of metabolic diseases such as diabetes.

M 16209

Cas No. 128851-36-5

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	M 16209 is an orally active aldose reductase (AR) inhibitor. It effectively inhibits partially purified aldose reductase from various sources, with IC50 values of 0.12 μM for rat lens AR, 0.24 μM for bovine lens AR, 4.5 μM for bovine kidney AR, 1.2 μM for canine lens AR, and 9.3 μM for human placental AR. M 16209 is applicable in the study of metabolic diseases such as diabetes.
In vivo	M 16209, administered orally at a dosage of 10-30 mg/kg once daily for 6 consecutive days, can prevent galactose-induced cataracts in male Sprague-Dawley rats. Additionally, M 16209, given at the same dosage and frequency for 14 consecutive days, can improve delayed motor nerve conduction velocity in male Wistar rats with streptozotocin-induced diabetic neuropathy.

Chemical Properties

Molecular Weight	359.15
Formula	C₁₁H₇BrN₂O₅S
Cas No.	128851-36-5
Smiles	O=C1NC(=O)CN1S(=O)(=O)C=2OC=3C=CC=CC3C2Br

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.