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Dicentrine, (-)-
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Catalog No. T20225Cas No. 28832-07-7
Alias NSC-251699, NSC251699, NSC 251699, L-Dicentrine
Dicentrine, (-)- (NSC-251699) is an aporphinic alkaloid found in several plant species, which showed significant antinociceptive activity in an acute model of visceral pain in mice.
Dicentrine, (-)-
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Purity: 99.86%
Catalog No. T20225Alias NSC-251699, NSC251699, NSC 251699, L-DicentrineCas No. 28832-07-7
Dicentrine, (-)- (NSC-251699) is an aporphinic alkaloid found in several plant species, which showed significant antinociceptive activity in an acute model of visceral pain in mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $247 | - | In Stock | |
| 10 mg | $367 | - | In Stock | |
| 25 mg | $595 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.86%
Appearance:Solid
Color:White
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Product Introduction
Dicentrine, (-)- AI Summary
Dicentrine, (-)- exhibits significant cytotoxicity against a range of human cell lines with ED50 values between 0.6 to 6.1 µg/ml after three days, highlighting its potential as an anticancer agent. It also shows notable antimalarial activity against both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with ED50 values of 1260.0 ng/ml and 2550.0 ng/ml, respectively. The compound demonstrates a selectivity for human KB cells over malaria parasite strains, with selectivity index ratios of 4.0 and 2.0. Beyond these, Dicentrine, (-)- is active in inhibiting a variety of biological targets and bioassays, including but not limited to Lamin A Splicing, JMJD2E, Tau Fibril Formation, ROR gamma transcriptional activity, and Lipid Storage in Drosophila S3 Cells. It also inhibits several enzymes such as Fructose-1,6-bisphosphate Aldolase from Giardia lamblia, AmpC Beta-Lactamase, DNA Polymerase Beta, and Dyrk1A Kinase. The compound induces growth inhibition in various human tumor cell lines, disrupts protein-protein interactions like ARNT/TAC3, and exerts antiviral effects against Hepatitis C Virus and Foot and Mouth Disease Virus. Additionally, it induces synthetic lethality in 2HG-producing tumor cells, inhibits key viral and bacterial proteins, and affects several cancer and normal cell processes, making it a multifunctional candidate for therapeutic development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dicentrine, (-)- (NSC-251699) is an aporphinic alkaloid found in several plant species, which showed significant antinociceptive activity in an acute model of visceral pain in mice. |
| Synonyms | NSC-251699, NSC251699, NSC 251699, L-Dicentrine |
| Molecular Weight | 339.39 |
| Formula | C20H21NO4 |
| Cas No. | 28832-07-7 |
| Smiles | CN1[C@]2(C=3C(C=4C(C2)=CC(OC)=C(OC)C4)=C5C(=CC3CC1)OCO5)[H] |
| Relative Density. | 1.266 g/cm3 at 20℃ |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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