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FTY720 (S)-Phosphate

Name: FTY720 (S)-Phosphate
Brand: TargetMol
SKU: T15354
Price: 169 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15354Cas No. 402616-26-6

Alias (S)-FTY720P, (S)-FTY720 phosphate

FTY720 (S)-Phosphate is the active stereoisomeric phosphate derivative of FTY720 that acts as a potent modulator of sphingosine-1-phosphate (S1P) receptors. FTY720 (S)-Phosphate binds to S1P receptor subtypes S1P1, S1P3, S1P4, and S1P5 with Ki values of 2.1, 5.9, 23, and 2.2 nM respectively, causing receptor internalization on lymphocytes， preventing S1P-mediated lymphocyte egress from lymphoid tissues. FTY720 (S)-Phosphate also enhances endothelial barrier integrity, stimulates transporters such as Abcb1 and Abcc1, and inhibits cytosolic phospholipase A2 activity, highlighting its multifunctional pharmacological properties, making it an compound of interest in the research of diseases including multiple sclerosis, autoimmune diseases and cancer.

FTY720 (S)-Phosphate

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Purity: 99.37%

Catalog No. T15354Alias (S)-FTY720P, (S)-FTY720 phosphateCas No. 402616-26-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$169	-	In Stock
2 mg	$253	-	In Stock
5 mg	$428	-	In Stock
10 mg	$687	-	In Stock
25 mg	$1,390	-	In Stock
50 mg	$2,230	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.37%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	FTY720 (S)-Phosphate is the active stereoisomeric phosphate derivative of FTY720 that acts as a potent modulator of sphingosine-1-phosphate (S1P) receptors. FTY720 (S)-Phosphate binds to S1P receptor subtypes S1P1, S1P3, S1P4, and S1P5 with Ki values of 2.1, 5.9, 23, and 2.2 nM respectively, causing receptor internalization on lymphocytes， preventing S1P-mediated lymphocyte egress from lymphoid tissues. FTY720 (S)-Phosphate also enhances endothelial barrier integrity, stimulates transporters such as Abcb1 and Abcc1, and inhibits cytosolic phospholipase A2 activity, highlighting its multifunctional pharmacological properties, making it an compound of interest in the research of diseases including multiple sclerosis, autoimmune diseases and cancer.
In vitro	FTY720 (S)-Phosphate (Tys, 1 μM) can preserve the expression level of S1PR1 protein and improve the barrier function of Homo sapiens pulmonary artery endothelial cells by activating S1PR1, without significantly affecting the ubiquitination process of S1PR1 at this concentration. Within the dose range of 0.01-50 μM, FTY720 (S)-Phosphate can inhibit the recruitment of β-arrestin to S1PR1 [1].
In vivo	FTY720 (S)-Phosphate (0.5 mg/kg, intraperitoneal injection) maintained the expression level of S1PR1 in mouse lung tissue, exerted protective effects against bleomycin-induced acute lung injury (ALI), and reduced the degree of leukocyte infiltration in the lung tissue of bleomycin-injured model mice [1].
Synonyms	(S)-FTY720P, (S)-FTY720 phosphate

Chemical Properties

Molecular Weight	387.45
Formula	C₁₉H₃₄NO₅P
Cas No.	402616-26-6
Smiles	C(C[C@@](COP(=O)(O)O)(CO)N)C1=CC=C(CCCCCCCC)C=C1
Relative Density.	1.172 g/cm3 (Predicted)

Storage & Solubility Information

Storage	The compound is unstable in solution. Please use soon \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: 0.5 mg/mL (slightly soluble), Sonication is recommended. H2O: < 1 mg/mL (insoluble)

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc