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PF-07202954
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Catalog No. T79764Cas No. 2639372-47-5
Alias PF07202954, PF 07202954
PF-07202954 is a DGAT2 inhibitor with a long half-life. Its IC50 values for human DGAT2 and rat DGAT2 are 10 nM and 9.1-33 nM respectively. It can reduce the triglyceride content in the liver of rats fed with a Western diet and can be used for the study of non-alcoholic fatty liver disease (NASH).
PF-07202954
😃Good
Purity: 98.99%
Catalog No. T79764Alias PF07202954, PF 07202954Cas No. 2639372-47-5
PF-07202954 is a DGAT2 inhibitor with a long half-life. Its IC50 values for human DGAT2 and rat DGAT2 are 10 nM and 9.1-33 nM respectively. It can reduce the triglyceride content in the liver of rats fed with a Western diet and can be used for the study of non-alcoholic fatty liver disease (NASH).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $5,859 | - | In Stock | |
| 50 mg | $8,208 | - | In Stock | |
| 100 mg | $11,498 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.99%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PF-07202954 is a DGAT2 inhibitor with a long half-life. Its IC50 values for human DGAT2 and rat DGAT2 are 10 nM and 9.1-33 nM respectively. It can reduce the triglyceride content in the liver of rats fed with a Western diet and can be used for the study of non-alcoholic fatty liver disease (NASH). |
| Targets&IC50 | DGAT-2 (human):10 nM, DGAT-2 (rat):9.1-33 nM |
| Synonyms | PF07202954, PF 07202954 |
| Molecular Weight | 438.45 |
| Formula | C22H23FN6O3 |
| Cas No. | 2639372-47-5 |
| Smiles | O(C1=CC(C=2N=CC(C(N[C@H]3C[C@H](F)CNC3)=O)=CN2)=CN=C1)C4=C(OCC)C=CC=N4 |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2.5 mg/mL (5.7 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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