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Telomerase-IN-9
Catalog No. T213980 Copy Product Info
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Telomerase-IN-9 is a potent and selective inhibitor of telomerase, effectively reducing telomerase activity by binding to hTERT, which results in diminished telomerase function. This compound induces apoptosis and inhibits colony formation. It has been shown to reduce tumor burden, restore antioxidant balance, and protect lung structure in a mouse model of lung cancer induced by Benzo[a]pyrene. Telomerase-IN-9 is applicable in lung cancer research.
Telomerase-IN-9
Copy Product Info🥰Excellent
Catalog No. T213980
Telomerase-IN-9 is a potent and selective inhibitor of telomerase, effectively reducing telomerase activity by binding to hTERT, which results in diminished telomerase function. This compound induces apoptosis and inhibits colony formation. It has been shown to reduce tumor burden, restore antioxidant balance, and protect lung structure in a mouse model of lung cancer induced by Benzo[a]pyrene. Telomerase-IN-9 is applicable in lung cancer research.
Telomerase-IN-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Telomerase-IN-9 is a potent and selective inhibitor of telomerase, effectively reducing telomerase activity by binding to hTERT, which results in diminished telomerase function. This compound induces apoptosis and inhibits colony formation. It has been shown to reduce tumor burden, restore antioxidant balance, and protect lung structure in a mouse model of lung cancer induced by Benzo[a]pyrene. Telomerase-IN-9 is applicable in lung cancer research. |
| In vitro | Telomerase-IN-9 (compound 28) exhibits potent and selective cytotoxicity against A549, MDA-MB-231, and NCI-H460 cell lines with IC 50 values of 0.043, 0.926, and 1.08 μM, respectively, while showing low cytotoxicity towards Vero cells (IC 50 > 25 μM). At concentrations of 5-10 μM over 48 hours, Telomerase-IN-9 induces apoptosis in A549 cells in a dose-dependent manner. At 10 μM, it significantly inhibits telomerase activity in A549 cells, with a fold change of 0.535. Moreover, Telomerase-IN-9 suppresses colony formation in A549 cells in a concentration-dependent way over 12 days at 3.75-25 μM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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