LGMN Protein, Human, Recombinant (His)

Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 371.00
500 μg	5 days	$ 1,490.00
1 mg	5 days	$ 2,480.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 371.00

500 μg

5 days

$ 1,490.00

1 mg

5 days

$ 2,480.00

Description

Species	Human
Expression System	HEK293
Tag	N-His
Accession Number	Q99538-1
Synonyms	AI746452, Legumain, LGMN1, Prsc1, AEP, LGMN, AU022324
Construction	Recombinant Human LGMN Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Val18-Tyr433.[Accession \|Q99538-1]
Protein Purity	> 95% as determined by Tris-Bis PAGE
Molecular Weight	The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Stability & Storage	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.