Neuropeptide Y Receptor

Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4.

Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.

Peptide YY (PYY) (3-36), human (Peptide YY (3-36)), is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

BWX 46 Acetate is a potent, highly selective neuropeptide Y (NPY) receptor agonist with IC50 of 0.5 nM.

BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).

Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide acetate dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide acetate appears to bind to a single population of SP receptors (KD~40 nM).

neuropeptide Y Y5 receptor antagonist

DF-1012 FA is a structural analog of DF-1012, a neuropeptide inhibitor used in the study of asthma and cough.

High affinity neuropeptide Y Y1 receptor agonist

(S)-VU0637120 is a selective neuropeptide Y(4)R-mutant antagonist used in the study of metabolic disorders.

neuropeptide S receptor (NPSR) antagonist

NTNCB hydrochloride is an antagonist of neuropeptide Y (NPY) Y5 receptor.

Velneperit (S2367) is potent and selective neuropeptide Y (NPY) Y5 receptor under evaluating for treatment of obesity.

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM).

Neuropeptide S (Mouse) acetate is a bioactive peptide. Neuropeptide S (Mouse) acetate, as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and drug addiction[1].

Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by ad

Galanin (1-16), mouse, porcine, rat, is a hippocampal galanin receptor agonist (Kd = 3 nM) exhibiting high biological activity on locus coeruleus neurons.

SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release.

Neuropeptide S (Rat) acetate is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) acetate can be used for the research of nervous system disease [1].

BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.

CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by its inability to displace iodinated galanin, or to induce IP1 accumulation on its own).

MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM).

HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target.

SF-22 is a neuropeptide Y receptor (Y2R) antagonist that crosses the blood-brain barrier and has potential anti-inflammatory activity for the study of diseases associated with neurological disorders.