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TargetMol | Tags GPCR/G Protein
TargetMol | Tags Neuroscience

Neuropeptide Y Receptor

Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

  • Y1 receptor antagonist 1
    T12155221697-09-2In house
    Y1 receptor antagonist 1 (H 409-22 isomer) is the active isomer of H-409/22, a neuropeptide Y (NPY) Y1 receptor antagonist that dose-dependently antagonizes the vascular response to exogenous and endogenous NPY in pigs. lagodeoxycholic acid (H 409-22 isomer) is the active isomer of H-409/22, an antagonist of neuropeptide Y (NPY) Y1 receptor.
    • $353
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  • RF9 acetate
    T16738L
    RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
    • $98
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  • Pancreatic Polypeptide (human) acetate
    TP1137L
    Pancreatic Polypeptide (human) acetate is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
    • $198
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  • RFRP-1 (human) acetate(311309-25-8 free base)
    TP1937L1
    RFRP-1 (human) acetate is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, eject
    • $133
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  • Neuropeptide SF(mouse,rat) acetate
    TP1884L1
    Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) is a potent neuropeptide FF receptor agonist, Ki for NPFF1 and NPFF2 are 48.4 nM and 12.1 nM, respectively. Neuropeptide SF(mouse,rat) acetate (Neuropeptide SF(mouse,rat) acetate (230960-31-3 free base)) increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3).
    • $133
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  • M617 acetate
    TP1993L
    M617 acetate is a selective agonist of galanin receptor 1 (GAL1). M617 acetate acts through central GAL1, promotes GLUT4 expression, and enhances GLUT4 content in the cardiac muscle of type 2 diabetic rats. The Ki values are 0.23 and 5.71 nM for GAL1 and GAL2, respectively.
    • $475
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  • Galantide acetate
    T15368L
    Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide acetate dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide acetate appears to bind to a single population of SP receptors (KD~40 nM).
    • $263
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  • BWX 46 Acetate
    T21611L
    BWX 46 Acetate is a potent, highly selective neuropeptide Y (NPY) receptor agonist with IC50 of 0.5 nM.
    • $253
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  • Galanin (1-16), mouse, porcine, rat
    TP1380125118-77-6
    Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons.
    • $167
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  • AR-M 1896 Acetate
    T21646L
    AR-M 1896 Acetate is the selective agonist of GalR2.
    • $941
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  • M 1145 acetate
    TP1991L
    M1145 acetate, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 acetate shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 acetate has an additive effect on the signal transduction of galanin[1].
    • $619
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  • [D-Trp34]-Neuropeptide Y Acetate
    TP1984L
    [D-Trp34]-Neuropeptide Y Acetate is a potent and selective agonist of neuropeptide Y (NPY) Y5 receptor. [D-Trp34]-Neuropeptide acetate Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y Acetate markedly increases food intake in rats.
    • $195
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  • Neuropeptide S (Rat) acetate
    TP1982L
    Neuropeptide S (Rat) acetate is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) acetate can be used for the research of nervous system disease [1].
    • $148
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  • Galanin Receptor Ligand M35 TFA
    TP1704
    Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).
    • $188
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  • M871 acetate
    TP1994L
    M871 acetate is a selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM at GAL2 and GAL1 receptors, respectively).It blocks pronociceptive effects of GAL2 agonists including AR-M1896.
    • $473
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  • Spexin acetate(1370290-58-6 free base)
    TP1930L1
    Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by ad
    • $193
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  • RFRP3(human) acetate(311309-27-0 free base)
    TP1936L1
    RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 n
    • $133
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  • Neuropeptide S (Mouse) acetate
    TP1981L
    Neuropeptide S (Mouse) acetate is a bioactive peptide. Neuropeptide S (Mouse) acetate, as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and drug addiction[1].
    • $148
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  • M40 acetate(143896-17-7 free base)
    TP1992L
    M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
    • $196
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  • Peptide YY (PYY) (3-36), human
    TP1059126339-09-1
    Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) is a gut hormone peptide. Peptide YY (PYY) (3-36), human acts as a Y2 receptor agonist to reduce appetite.
    • $76
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  • Neuropeptide FF acetate(99566-27-5 free base)
    TP1074L
    Neuropeptide FF acetate(99566-27-5 free base) (NPFF acetate) is an octapeptide belonging to the RF amide family. NPFF interacts with G-protein-coupled receptors NPFF (1) and NPFF (2).
    • $147
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  • DF-1012 FA
    T27158L In house
    DF-1012 FA is a structural analog of DF-1012, a neuropeptide inhibitor used in the study of asthma and cough.
    • $195 TargetMol
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  • Neuropeptide Y (29-64), amide, human acetate
    TP1140L
    Neuropeptide Y (29-64), amide, human acetate is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
    • $167
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  • Pancreatic Polypeptide, rat acetate
    TP1044L
    Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4.
    • $397
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  • Selvigaltin
    T637511978336-95-6In house
    Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.
    • $289
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  • [Leu31,Pro34]-Neuropeptide Y (porcine)
    TP2206125580-28-1
    High affinity neuropeptide Y Y1 receptor agonist
    • $58
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  • AC-099 hydrochloride
    T83212849335-07-5
    AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological....
    • $40
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  • ML 154
    T229941345964-89-7
    neuropeptide S receptor (NPSR) antagonist
    • $89
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  • AC-263093
    T83651849459-86-5
    AC-263093 is an NPFFR2 agonist with anxiolytic activity that increases c-Fos protein expression in the paraventricular nucleus of the hypothalamus.
    • $40
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  • L 152804
    T156796508-43-6
    L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice.
    • $31
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  • WAY-639889
    T77783432506-24-6
    WAY-639889 is a small molecule compound with selective and potent inhibitory effects on neuropeptide Y-5 receptors.
    • $48
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  • BMS 193885
    T22608679839-66-8
    BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM.
    • $840
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  • Galanin (1-13)-Neuropeptide Y (25-36) amide
    T80143147138-51-0
    Galanin (1-13)-Neuropeptide Y (25-36) amide exhibits high-affinity binding to galanin receptors, similar to that of galanin itself [1].
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  • Galanin-Like Peptide (porcine)
    T80145245114-96-9
    Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide originally isolated from the porcine hypothalamus. It exhibits a high affinity for the GALR2 receptor with an IC 50 of 0.24 nM and a comparatively lower affinity for the GALR1 receptor, with an IC 50 of 4.3 nM [1].
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  • HT-2157
    T5455303149-14-6
    HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target.
    • $51
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  • Velneperit
    T17222342577-38-2
    Velneperit (S2367) is potent and selective neuropeptide Y (NPY) Y5 receptor under evaluating for treatment of obesity.
    • $31
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  • JNJ-31020028
    T19971094873-14-9
    JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors.
    • $31
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  • BIBO3304 TFA
    T10539191868-14-1
    BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).
    • $98
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  • NPY 5RA972
    T23087439861-56-0
    neuropeptide Y Y5 receptor antagonist
    • $78
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  • CGP71683 hydrochloride
    T5587192322-50-2
    CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
    • $46
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  • Ala5-Galanin (2-11)
    T80517859843-84-8
    Ala5-Galanin (2-11) is a specific agonist for the galanin receptor 2 (GAL2R) with an affinity constant (Ki) of 258 nM [1].
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  • BMS-193885
    T14671186185-03-5
    BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.
    • $48
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  • GALNON
    T8456475115-35-6
    Galnon is a galanin receptor agonist, improves intrinsic cortical bone tissue properties
    • $817
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  • NTNCB hydrochloride
    T23094191931-56-3
    NTNCB hydrochloride is an antagonist of neuropeptide Y (NPY) Y5 receptor.
    • $45
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  • Galanin-Like Peptide (rat)
    T80146245114-97-0
    Galanin-Like Peptide (rat), a neuropeptide comprising 60 amino acids, plays a crucial role in regulating feeding, body weight, and energy metabolism [1].
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  • (Leu31,Pro34)-Peptide YY (human) (TFA)
    T80087
    (Leu31,Pro34)-Peptide YY (human) (TFA) is the trifluoroacetic acid (TFA) form of (Leu31,Pro34)-Peptide YY (human), a derivative of Peptide YY that acts as a potent and selective Y1 agonist, exhibiting a dissociation constant (K D) of 1.0 nM [1].
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  • human GALP (3-32)
    T80516
    Human GALP (3-32) (Galanin-like peptide (3-32)) serves as a high-affinity agonist for galanin receptors GalR1 (IC50 = 33 nM) and GalR2 (IC50 = 15 nM), as evidenced by competitive binding studies. It demonstrates significant potency in modifying the extracellular acidification rate in SH-SY5Y cells expressing GalR2 (EC50 = 360 nM) [1].
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  • CYM2503
    T89631308833-36-4
    CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by its inability to displace iodinated galanin, or to induce IP1 accumulation on its own).
    • $51
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  • GW438014A
    T24121469861-49-2
    GW438014A is a potent, selective antagonist of the NPY-Y5 receptor, effectively inhibiting food consumption and curbing body weight gain in obese rodents.
    • $34
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  • SF-22
    T71749824981-55-7
    SF-22 is a neuropeptide Y receptor (Y2R) antagonist that crosses the blood-brain barrier and has potential anti-inflammatory activity for the study of diseases associated with neurological disorders.
    • $30
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