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Bisabolangelone

Name: Bisabolangelone
Brand: TargetMol
SKU: TN1445
Price: 278 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1445Cas No. 30557-81-4

Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

Bisabolangelone

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Purity: 98.91%

Catalog No. TN1445Cas No. 30557-81-4

Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$164	In Stock	In Stock
25 mg	$278	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$96	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.91%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

In vitro

Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling[2].

Chemical Properties

Molecular Weight	248.32
Formula	C₁₅H₂₀O₃
Cas No.	30557-81-4
Smiles	[H][C@]12CC(C)=CC(=O)[C@@]1([H])[C@@](C)(O)\C(O2)=C\C=C(C)C
Relative Density.	1.154 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (100.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0271 mL	20.1353 mL	40.2706 mL	201.3531 mL
5 mM	0.8054 mL	4.0271 mL	8.0541 mL	40.2706 mL
10 mM	0.4027 mL	2.0135 mL	4.0271 mL	20.1353 mL
20 mM	0.2014 mL	1.0068 mL	2.0135 mL	10.0677 mL
50 mM	0.0805 mL	0.4027 mL	0.8054 mL	4.0271 mL
100 mM	0.0403 mL	0.2014 mL	0.4027 mL	2.0135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc