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Anti-Alpha-2-macroglobulin Antibody (4X593)
😃Good
Catalog No. TMAY-01377
Alias α-2-macroglobulin, S863-7, FWP007, CPAMD5, alpha-2-macroglobulin, A2MD
Anti-Alpha-2-macroglobulin Antibody (4X593) is a Rabbit antibody targeting Alpha-2-macroglobulin. Anti-Alpha-2-macroglobulin Antibody (4X593) can be used in ELISA.
Anti-Alpha-2-macroglobulin Antibody (4X593)
Anti-Alpha-2-macroglobulin Antibody (4X593)
😃Good
Catalog No. TMAY-01377Alias α-2-macroglobulin, S863-7, FWP007, CPAMD5, alpha-2-macroglobulin, A2MD
Anti-Alpha-2-macroglobulin Antibody (4X593) is a Rabbit antibody targeting Alpha-2-macroglobulin. Anti-Alpha-2-macroglobulin Antibody (4X593) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $93 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Alpha-2-macroglobulin Antibody (4X593) is a Rabbit antibody targeting Alpha-2-macroglobulin. Anti-Alpha-2-macroglobulin Antibody (4X593) can be used in ELISA. |
| Alias | α-2-macroglobulin, S863-7, FWP007, CPAMD5, alpha-2-macroglobulin, A2MD |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4X593 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human alpha-2-macroglobulin / A2M (rh alpha-2-macroglobulin / A2M; TMPY-02063; NP_000005.2; Met1-Ala1474). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance, alpha2-macroglobulin binds a variety of other ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human alpha-2-macroglobulin / A2M Protein (TMPY-02063) |
| Antigen Species | Human |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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