Shopping Cart

Your shopping cart is currently empty

Diloxanide furoate

Name: Diloxanide furoate
Brand: TargetMol
SKU: T15131
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T15131Cas No. 3736-81-0

Alias Diloxanide, Dichlofurazol, Amebamide

Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.

Diloxanide furoate

Copy Product Info

😃Good

Purity: 99.39%

Catalog No. T15131Alias Diloxanide, Dichlofurazol, AmebamideCas No. 3736-81-0

Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$40	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$129	In Stock	In Stock
100 mg	$193	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.39%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Diloxanide furoate (Dichlofurazol) is an antiprotozoal compound with oral activity that can be used in the study of amoebas in tissues and several other protozoal infections.
Targets&IC50	SFL3 strain cultured aseptically:1.95 μg/ml (MIC), SFL3 strain co-cultivated with Trypanosoma cruzi:2.5 μg/ml (MIC), BYso strain co-cultivated with bacteria:2.5 μg/ml (MIC)
In vitro	Diloxanide furoate showed significant activity against different strains of Tissue Lysing Ameba in the concentration range of 1.95 to 2.5 μg/ml. The minimum inhibitory concentration (MIC) was 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml for BYso strain co-cultivated with bacteria, SFL3 strain co-cultivated with Trypanosoma cruzi and SFL3 strain cultured aseptically. [1]
In vivo	Diloxanide furoate administered orally at doses ranging from 75-200 mg/kg once daily for 3 consecutive days showed efficacy in weanling pups at different doses. Administered at a dose of 200 mg/kg, 100% of the subject rats were cured and no amebic lesions were observed in the cecum. In addition, the cure rate was 85%, 77% and 44.4% when administered at doses of 150 mg/kg, 100 mg/kg and 75 mg/kg, respectively. The half effective dose (ED50) of the drug in rats was 77.9 mg/kg. [1]
Synonyms	Diloxanide, Dichlofurazol, Amebamide

Chemical Properties

Molecular Weight	328.15
Formula	C₁₄H₁₁Cl₂NO₄
Cas No.	3736-81-0
Smiles	O=C(OC1=CC=C(C=C1)N(C(=O)C(Cl)Cl)C)C=2OC=CC2
Relative Density.	1.424 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 10 mg/mL (30.47 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

DMSO: 40 mg/mL (121.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0474 mL	15.2369 mL	30.4739 mL	152.3693 mL
5 mM	0.6095 mL	3.0474 mL	6.0948 mL	30.4739 mL
10 mM	0.3047 mL	1.5237 mL	3.0474 mL	15.2369 mL
20 mM	0.1524 mL	0.7618 mL	1.5237 mL	7.6185 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0609 mL	0.3047 mL	0.6095 mL	3.0474 mL
100 mM	0.0305 mL	0.1524 mL	0.3047 mL	1.5237 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc