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SB 452533

Name: SB 452533
Brand: TargetMol
SKU: T23322
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23322Cas No. 459429-39-1

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).

SB 452533

🥰Excellent

Purity: 99.87%

Catalog No. T23322Cas No. 459429-39-1

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$58	In Stock
10 mg	$98	In Stock
25 mg	$193	In Stock
50 mg	$298	In Stock
100 mg	$433	In Stock
200 mg	$616	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Batch Information

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Purity:99.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
Targets&IC50	TRPV1:7.8(pKb)
In vitro	SB 452533 significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2[1].
In vivo	Small dose Cap significantly reduced bleomycin-induced pulmonary fibrosis in mice and obviously reversed alveolar epithelial cells epithelial-mesenchymal transition (EMT) (the expression of E-cadherin and ZO-1 were increased(P＜0.05 or P＜0.01)and the expression of α-SMA and Vimentin were decreased (P＜0.05 or P＜0.01) after drugs treatment for 21 day, concomitantly with the increase the expressions of TRPV1 and CGRP (P＜0.05 or P＜0.01), and inhibiting ERK1/2 phosphorylation and eIF3a expression (P＜0.05 or P＜0.01). These effects of small dose Cap were abolished in the presence of TRPV1 receptor antagonist SB 452533[2].

Chemical Properties

Molecular Weight	376.29
Formula	C₁₈H₂₂BrN₃O
Cas No.	459429-39-1
Smiles	CCN(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1
Relative Density.	1.347 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (159.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6575 mL	13.2876 mL	26.5752 mL	132.8762 mL
5 mM	0.5315 mL	2.6575 mL	5.3150 mL	26.5752 mL
10 mM	0.2658 mL	1.3288 mL	2.6575 mL	13.2876 mL
20 mM	0.1329 mL	0.6644 mL	1.3288 mL	6.6438 mL
50 mM	0.0532 mL	0.2658 mL	0.5315 mL	2.6575 mL
100 mM	0.0266 mL	0.1329 mL	0.2658 mL	1.3288 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc