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Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody

(Synonyms: p-Alpha-Synuclein (Y125), p-Alpha-Synuclein (Tyr125), Alpha-Synuclein (p-Y125), Alpha-Synuclein (p-Tyr125)) Copy Product Info
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Synonyms: p-Alpha-Synuclein (Y125), p-Alpha-Synuclein (Tyr125), Alpha-Synuclein (p-Y125), Alpha-Synuclein (p-Tyr125)

Catalog No. TMAC-00291 Copy Product Info
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Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Alpha-Synuclein (Tyr125). Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody can be used in IF,WB.

Anti-Phospho-Alpha-Synuclein
(Tyr125) Polyclonal Antibody

Pack SizePriceUSA StockGlobal StockQuantity
50 µL$2187-10 days7-10 days
100 µL$3177-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Alpha-Synuclein (Tyr125). Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody can be used in IF,WB.
Synonymsp-Alpha-Synuclein (Y125), p-Alpha-Synuclein (Tyr125), Alpha-Synuclein (p-Y125), Alpha-Synuclein (p-Tyr125)
Ig Type
IgG
Reactivity
Human
Verified Activity
1. Western blot analysis of extracts from C2C12 cells untreated or treated with Anisomycin using a-Synuclein (Phospho-Tyr125) Antibody TMAC-00291.
2. Immunofluorescence staining of methanol-fixed Hela cells using a-Synuclein (Phospho-Tyr125) Antibody TMAC-00291.
Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody,Anti-Phospho-Alpha-Synuclein (Tyr125) Polyclonal Antibody
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M) derived from Human a-Synuclein
Antigen Species
Human
Uniprot ID
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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