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MLN-3897 TFA

Catalog No. T28072L

Synonyms: MLN-3897 TFA(1010731-97-1 Free base)

MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MLN-3897 TFA, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 430.00
10 mg	In stock	$ 636.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00
500 mg	In stock	$ 3,680.00
1 mL * 10 mM (in DMSO)	In stock	$ 592.00

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Purity: 98.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.

Synonyms	MLN-3897 TFA(1010731-97-1 Free base)
Molecular Weight	633.05
Formula	C32H32ClF3N2O6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.33 mg/mL (10 mM)

References and Literature

1. Gilchrist A, et al. Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays. Br J Pharmacol. 2014 Nov;171(22):5127-38.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

BX471 CCR1 antagonist 6 Maraviroc YM022 Bindarit TAK-779 CCX140 R243

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MLN-3897 TFA Immunology/Inflammation Microbiology/Virology CCR MLN-3897 TFA(1010731-97-1 Free base) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.