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Anti-Cofilin 1 Antibody (3R946)
Catalog No. TMAB-04508 Copy Product Info
🥰Excellent
Anti-Cofilin 1 Antibody (3R946) is a Rabbit antibody targeting Cofilin 1. Anti-Cofilin 1 Antibody (3R946) can be used in WB,FCM.
Anti-Cofilin 1 Antibody (3R946)
Copy Product Info🥰Excellent
Catalog No. TMAB-04508
Anti-Cofilin 1 Antibody (3R946) is a Rabbit antibody targeting Cofilin 1. Anti-Cofilin 1 Antibody (3R946) can be used in WB,FCM.
Anti-Cofilin 1 Antibody
(3R946)
(3R946)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-Cofilin 1 Antibody (3R946) is a Rabbit antibody targeting Cofilin 1. Anti-Cofilin 1 Antibody (3R946) can be used in WB,FCM. |
| Ig Type | IgG |
| Clone | 3R946 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Verified Activity | 1. Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1: 2000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HeLa, 2: MCF-7, 3: 293T, 4: C6,5: NIH/3T3 Protein loading quantity: 20 μg Exposure time: 3 s Predicted MW: 19 kDa Observed MW: 19 kDa 2. Cell line: HeLa Fixation: 4% Paraformaldehyde Permeabilization: 90% Methanol Primary Ab dilution: 1:100 Secondary Ab: Goat Anti-Rabbit IgG Unlabelled control: The cell without incubation with primary antibody and secondary antibody (Black line). Isotype control: Rabbit monoclonal IgG (Blue line). Comment: Line red is the positive signal for TMAB-04508 |
| Application | |
| Recommended Dose | WB: 1:500-2000; FCM: 1:20-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. |
| Tissue Specificity | Widely distributed in various tissues. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. |
| Gene Name | CFL1 |
| Gene ID | |
| Protein Name | Cofilin-1 |
| Function | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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