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GLP-26

🥰Excellent
Catalog No. T11409Cas No. 2133017-36-2

GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library.

GLP-26

GLP-26

🥰Excellent
Purity: 98.62%
Catalog No. T11409Cas No. 2133017-36-2
GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$100In StockIn Stock
5 mg$233In StockIn Stock
10 mg$318In StockIn Stock
25 mg$493In StockIn Stock
50 mg$719In StockIn Stock
100 mg$987In StockIn Stock
200 mg$1,330In StockIn Stock
1 mL x 10 mM (in DMSO)$216In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.62%
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Product Introduction

Bioactivity
Description
GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library.
Targets&IC50
HBV:0.7 μM(EC50), HBV:3 nM
In vitro
Administration of 0.7-1.7 μM GLP-26 for 3 days reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type with EC50 values of 0.7 μM[1].
Chemical Properties
Molecular Weight373.35
FormulaC19H17F2N3O3
Cas No.2133017-36-2
SmilesCc1c(C(=O)C(=O)NCC#C)c(C)n(C)c1C(=O)Nc1ccc(F)c(F)c1
Relative Density.1.26 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (267.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.71 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6785 mL13.3923 mL26.7845 mL133.9226 mL
5 mM0.5357 mL2.6785 mL5.3569 mL26.7845 mL
10 mM0.2678 mL1.3392 mL2.6785 mL13.3923 mL
20 mM0.1339 mL0.6696 mL1.3392 mL6.6961 mL
50 mM0.0536 mL0.2678 mL0.5357 mL2.6785 mL
100 mM0.0268 mL0.1339 mL0.2678 mL1.3392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHepatitis B virusHBVGLP-26GLP26GLP 26
Related Tags: buy GLP-26 | purchase GLP-26 | GLP-26 cost | order GLP-26 | GLP-26 chemical structure | GLP-26 in vitro | GLP-26 formula | GLP-26 molecular weight
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