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IDO1-IN-7
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Catalog No. T39888Cas No. 2351199-98-7
Alias IDO1-IN-7
IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
IDO1-IN-7
Copy Product Info😃Good
Catalog No. T39888Alias IDO1-IN-7Cas No. 2351199-98-7
IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research. |
| Targets&IC50 | IDO1 (SKOV3 cells):6.1 nM (IC50) |
| In vitro | IDO1-IN-7 demonstrates moderate effectiveness in inhibiting target activity in a human whole blood assay, achieving an IC50 of 330 nM[1]. It also exhibits a favorable profile, characterized by good metabolic stability and satisfactory off-target selectivity[1]. Moreover, IDO1-IN-7 displays high specificity for IDO1, significantly outperforming tryptophan 2,3-dioxygenase (TDO) with an IC50 of 14,000 nM, highlighting its selectivity[1]. |
| In vivo | IDO1-IN-7, administered orally at a dosage of 10 mg/kg, demonstrates a maximal concentration (C max) of 10.0 μM and an area under the curve (AUC) from 0 to 8 hours of 27.1 μM*h, with a half-life (t 1/2) of 1.4 hours in mice. [1] This pharmacokinetic analysis was conducted in a mouse model. |
| Synonyms | IDO1-IN-7 |
| Molecular Weight | 427.86 |
| Formula | C22H19ClFN3O3 |
| Cas No. | 2351199-98-7 |
| Smiles | O[C@H]1CN(CC[C@@H]1c1ccnc2ccc(F)cc12)C(=O)C(=O)Nc1ccc(Cl)cc1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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