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(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

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Catalog No. T7185Cas No. 916210-98-5

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

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Purity: 97.23%
Catalog No. T7185Cas No. 916210-98-5
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$36In StockIn Stock
50 mg$48In StockIn Stock
100 mg$68In StockIn Stock
500 mg$159-In Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.23%
Appearance:Solid
Color:Yellow
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Product Introduction

Bioactivity
Description
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.
Targets&IC50
LOXL2:126 nM
In vitro
(2-Chloropyridin-4-yl)methanamine hydrochloride (hLOXL2 IC50 = 126 nM), was shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO).
Chemical Properties
Molecular Weight179.05
FormulaC6H8Cl2N2
Cas No.916210-98-5
SmilesCl.NCc1ccnc(Cl)c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (335.1 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 5 mg/mL (27.93 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.5850 mL27.9252 mL55.8503 mL279.2516 mL
5 mM1.1170 mL5.5850 mL11.1701 mL55.8503 mL
10 mM0.5585 mL2.7925 mL5.5850 mL27.9252 mL
20 mM0.2793 mL1.3963 mL2.7925 mL13.9626 mL
50 mM0.1117 mL0.5585 mL1.1170 mL5.5850 mL
100 mM0.0559 mL0.2793 mL0.5585 mL2.7925 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MonoamineOxidaseMonoamine OxidaseMAOLOXL2Inhibitorinhibit(2-Chloropyridin-4-yl)MethanaMine Hydrochloride(2Chloropyridin4yl)MethanaMine Hydrochloride(2 Chloropyridin 4 yl)MethanaMine Hydrochloride
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