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(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

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Catalog No. T7185Cas No. 916210-98-5

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

🥰Excellent
Purity: 97.23%
Catalog No. T7185Cas No. 916210-98-5
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$36In StockIn Stock
50 mg$48In StockIn Stock
100 mg$68In StockIn Stock
500 mg$159-In Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.23%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.
Targets&IC50
LOXL2:126 nM
In vitro
(2-Chloropyridin-4-yl)methanamine hydrochloride (hLOXL2 IC50 = 126 nM), was shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO).
Chemical Properties
Molecular Weight179.05
FormulaC6H8Cl2N2
Cas No.916210-98-5
SmilesCl.NCc1ccnc(Cl)c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (335.1 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 5 mg/mL (27.93 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.5850 mL27.9252 mL55.8503 mL279.2516 mL
5 mM1.1170 mL5.5850 mL11.1701 mL55.8503 mL
10 mM0.5585 mL2.7925 mL5.5850 mL27.9252 mL
20 mM0.2793 mL1.3963 mL2.7925 mL13.9626 mL
50 mM0.1117 mL0.5585 mL1.1170 mL5.5850 mL
100 mM0.0559 mL0.2793 mL0.5585 mL2.7925 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MonoamineOxidaseMonoamine OxidaseMAOLOXL2Inhibitorinhibit(2-Chloropyridin-4-yl)MethanaMine Hydrochloride(2Chloropyridin4yl)MethanaMine Hydrochloride(2 Chloropyridin 4 yl)MethanaMine Hydrochloride
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