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PD 123319

Name: PD 123319
Brand: TargetMol
SKU: T6067
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6067Cas No. 130663-39-7

Alias PD123319, (S)-(+)-PD 123319

PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.

PD 123319

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Purity: 99.65%

Catalog No. T6067Alias PD123319, (S)-(+)-PD 123319Cas No. 130663-39-7

PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$231	In Stock	In Stock
50 mg	$300	In Stock	In Stock
100 mg	$390	In Stock	In Stock
200 mg	$555	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.
Targets&IC50	AT2 receptor:34 nM
In vitro	Intravenous administration of PD 123319 to conscious hypertensive rats caused an immediate dose-dependent increase in MAP, and this effect was maintained for approximately 7.4 min with 3 mg/kg of PD 123319.PD 123319 had no effect on the self-regulation of cerebral blood flow.
In vivo	125I-AII specifically labeled two classes of AII binding sites in bovine adrenal glomerular cell membrane preparations. The first class (DuP-753-sensitive) accounted for approximately 85% of the total AII binding sites and had a high affinity for DuP-753 (IC 50 of 92.9 nM).PD-123319 had no effect on the binding of 125I-AII to this site. The second type of binding site is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 of about 10 μM).
Synonyms	PD123319, (S)-(+)-PD 123319

Chemical Properties

Molecular Weight	508.61
Formula	C₃₁H₃₂N₄O₃
Cas No.	130663-39-7
Smiles	C(N1C2=C(CN(C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@H](C(O)=O)C2)N=C1)C5=CC(C)=C(N(C)C)C=C5
Relative Density.	1.22 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (108.14 mM), Sonication is recommended.

H2O: 196.6 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9661 mL	9.8307 mL	19.6614 mL	98.3072 mL
5 mM	0.3932 mL	1.9661 mL	3.9323 mL	19.6614 mL
10 mM	0.1966 mL	0.9831 mL	1.9661 mL	9.8307 mL
20 mM	0.0983 mL	0.4915 mL	0.9831 mL	4.9154 mL
50 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9661 mL
100 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.9831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc