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PD 123319

Name: PD 123319
Brand: TargetMol
SKU: T6067
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6067Cas No. 130663-39-7

Alias PD123319, (S)-(+)-PD 123319

PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.

PD 123319

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Purity: 99.65%

Catalog No. T6067Alias PD123319, (S)-(+)-PD 123319Cas No. 130663-39-7

PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$231	In Stock	In Stock
50 mg	$300	In Stock	In Stock
100 mg	$390	In Stock	In Stock
200 mg	$555	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.
Targets&IC50	AT2 receptor:34 nM
In vitro	Intravenous administration of PD 123319 to conscious hypertensive rats caused an immediate dose-dependent increase in MAP, and this effect was maintained for approximately 7.4 min with 3 mg/kg of PD 123319.PD 123319 had no effect on the self-regulation of cerebral blood flow.
In vivo	125I-AII specifically labeled two classes of AII binding sites in bovine adrenal glomerular cell membrane preparations. The first class (DuP-753-sensitive) accounted for approximately 85% of the total AII binding sites and had a high affinity for DuP-753 (IC 50 of 92.9 nM).PD-123319 had no effect on the binding of 125I-AII to this site. The second type of binding site is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 of about 10 μM).
Synonyms	PD123319, (S)-(+)-PD 123319

Chemical Properties

Molecular Weight	508.61
Formula	C₃₁H₃₂N₄O₃
Cas No.	130663-39-7
Smiles	C(N1C2=C(CN(C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@H](C(O)=O)C2)N=C1)C5=CC(C)=C(N(C)C)C=C5
Relative Density.	1.22 g/cm3
Color	Yellow
Appearance	Viscous

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (108.14 mM), Sonication is recommended.

H2O: 196.6 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9661 mL	9.8307 mL	19.6614 mL	98.3072 mL
5 mM	0.3932 mL	1.9661 mL	3.9323 mL	19.6614 mL
10 mM	0.1966 mL	0.9831 mL	1.9661 mL	9.8307 mL
20 mM	0.0983 mL	0.4915 mL	0.9831 mL	4.9154 mL
50 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9661 mL
100 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.9831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc