Umbralisib hydrochloride

Name: Umbralisib hydrochloride
Brand: TargetMol
SKU: T17066
Rating: 4.5 (1 reviews)

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Catalog No. T17066Cas No. 1532533-78-0

Alias TGR-1202 hydrochloride, RP5264 hydrochloride

Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM).

Umbralisib hydrochloride

😃Good

Catalog No. T17066Alias TGR-1202 hydrochloride, RP5264 hydrochlorideCas No. 1532533-78-0

Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$53	5 days	5 days

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Product Introduction

Bioactivity

Description	Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM).
Targets&IC50	PI3Kδ:22.2 nM, PI3Kα:>10000 nM (Kd), PI3Kδ:6.2 nM (Kd), PI3Kβ:>10000 nM (Kd), PI3Kγ:1400 nM (Kd)
Synonyms	TGR-1202 hydrochloride, RP5264 hydrochloride

Chemical Properties

Molecular Weight	608.01
Formula	C₃₁H₂₅ClF₃N₅O₃
Cas No.	1532533-78-0
Smiles	Cl.CC(C)Oc1ccc(cc1F)-c1nn([C@@H](C)c2oc3ccc(F)cc3c(=O)c2-c2cccc(F)c2)c2ncnc(N)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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