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Anti-TSPAN8 Antibody
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Catalog No. T9901A-1459
Anti-TSPAN8 Antibody is a humanized monoclonal antibody that binds specifically to TSPAN8 (Tetraspanin-8) with high affinity. This product effectively inhibits TSPAN8-mediated cancer cell stemness and distant metastasis. By blocking TSPAN8 signaling, the antibody downregulates the expression of stemness markers and attenuates the invasive capacity of tumor cells, serving as a pharmacological tool for researching the progression of colorectal cancer and other malignancies.
Anti-TSPAN8 Antibody
Anti-TSPAN8 Antibody
Copy Product Info🥰Excellent
Catalog No. T9901A-1459
Anti-TSPAN8 Antibody is a humanized monoclonal antibody that binds specifically to TSPAN8 (Tetraspanin-8) with high affinity. This product effectively inhibits TSPAN8-mediated cancer cell stemness and distant metastasis. By blocking TSPAN8 signaling, the antibody downregulates the expression of stemness markers and attenuates the invasive capacity of tumor cells, serving as a pharmacological tool for researching the progression of colorectal cancer and other malignancies.
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| Description | Anti-TSPAN8 Antibody is a humanized monoclonal antibody that binds specifically to TSPAN8 (Tetraspanin-8) with high affinity. This product effectively inhibits TSPAN8-mediated cancer cell stemness and distant metastasis. By blocking TSPAN8 signaling, the antibody downregulates the expression of stemness markers and attenuates the invasive capacity of tumor cells, serving as a pharmacological tool for researching the progression of colorectal cancer and other malignancies. |
| In vitro | In cell-based assays using colorectal cancer cell lines (such as HCT116 and SW480),Anti-TSPAN8 Antibody effectively reduces the expression of stemness-related transcription factors (e.g., Sox2, Oct4, and Nanog) and inhibits ALDH1 activity, leading to a significant decrease in sphere formation and transwell invasion [1]. |
| In vivo | In pharmacological studies using orthotopic and tail-vein injection mouse models of colorectal cancer, systemic administration of Anti-TSPAN8 Antibody significantly inhibited primary tumor growth and markedly reduced the number of lung and liver metastatic foci; the treatment resulted in the downregulation of stemness markers within the tumor tissues, confirming its efficacy in suppressing metastasis by targeting the TSPAN8-mediated stemness signaling pathway [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | TSPAN8 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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