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Anti-CCR5 Polyclonal Antibody
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Catalog No. TMAB-00325
Alias IDDM22, CMKBR5, CKR-5, CKR5, CD195, CCR-5, CC-CKR-5, CCCKR5
Anti-CCR5 Polyclonal Antibody is a Rabbit antibody targeting CCR5. Anti-CCR5 Polyclonal Antibody can be used in WB.
Anti-CCR5 Polyclonal Antibody
Anti-CCR5 Polyclonal Antibody
😃Good
Catalog No. TMAB-00325Alias IDDM22, CMKBR5, CKR-5, CKR5, CD195, CCR-5, CC-CKR-5, CCCKR5
Anti-CCR5 Polyclonal Antibody is a Rabbit antibody targeting CCR5. Anti-CCR5 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CCR5 Polyclonal Antibody is a Rabbit antibody targeting CCR5. Anti-CCR5 Polyclonal Antibody can be used in WB. |
| Synonyms | IDDM22, CMKBR5, CKR-5, CKR5, CD195, CCR-5, CC-CKR-5, CCCKR5 |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | Sample: Lane 1: Human THP-1 cell lysates Lane 2: Human U937 cell lysates Primary: Anti-CCR-5 (TMAB-00325) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 43 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthetic peptide: human CCR-5 |
| Antigen Species | Human |
| Gene Name | CCR5 |
| Gene ID | |
| Protein Name | C-C chemokine receptor type 5 |
| Uniprot ID | |
| Biology Area | GPCR,Chemokines,HIV-related,Beta Chemokine Rec. (CCR),Macrophage / Inflamm.,Host Virus Interaction,Alzheimer's disease,GPCR |
| Function | Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. |
| Molecular Weight | Theoretical: 40 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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